مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Review The role of CeRNA in cancer development and progression
Review The role of CeRNA in cancer development and progression
ramesh ranjbar,1,*
1. department of biology, ShK.C., Islamik azad university, shahrekord, iran
Introduction: In mammals, a large part of the gene expression products are non-protein-coding ribonucleotide sequences. 80% of the total transcripts produced in the cell are related to the non-coding part.
Studies of the conservation of different classes of nCRNA among different vertebrates show that they are highly conserved between species, implying that their activity is not relevant to humans.
In one classification, non-coding RNAs are classified into two classes: housekeeping and regulatory. Another classification of non-coding RNAs is based on the size of the transcript.
lncRNA interacts with other molecules through its specific molecular structure and thus affects a number of important cellular processes, all mechanisms of which are examined in this study.
In general, different classes of ncRNAs play an important role in the control of gene expression through molecular interactions with DNA, RNA, and proteins, such as changing chromatin structure and regulating transcription, and controlling the translation process. They also have different modes of gene expression regulation. Many ncRNAs have diverse activities in the field of epigenetics. Some of them can interact with chromatin-modifying enzymes and cause changes in the transcriptional activity of some genes or the silencing of others. Or, they act on post-transcriptional events such as mRNA processing and degradation through interaction with processing factors and 3'UTR elements, respectively. They control the initiation or elongation of transcription by interfering with the RNAPOL transcriptional machinery.
Methods: This research is a review study and in this research, databases such as NCBI, PUBMED, etc. were used to collect information.
Results: Investigating the function of lnCRNA as an important component in intracellular processes, especially the regulation of gene expression in a variety of diseases, especially cancer.
Conclusion: CeRNA/miRNA/mRNA interactions maintain the overall activity and balance of gene networks in a cell, so aberrant expression of any component of this network can throw complex regulatory events out of whack and lead to cancer development.