مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
potential ability of umbilical cord-derived mesenchymal stem cells in the treatment of premature ovarian failure
potential ability of umbilical cord-derived mesenchymal stem cells in the treatment of premature ovarian failure
samira mozaffari khosravi,1saman seyedabadi,2marzieh lotfi,3,*hossein shahcheraghi,4
1. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran 2. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran 3. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran 4. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran
Introduction: Women of reproductive age may encounter challenges related to infertility or miscarriage, due to conditions such as premature ovarian failure (POF). POF, affecting approximately one percent of women under the age of 40, can lead to infertility. Current data suggests that utilizing stem cell therapy is the most effective approach for treating POF compared to alternative options. Among the various stem cell types, mesenchymal stem cells derived from the umbilical cord (HUC-MSCs) is a promising choice for treatment due to its features such as relatively low immunogenicity, multipotent, multiple origins, cost-effectiveness, ease of production, and high efficiency.
Methods: In this study, studies in this field were searched using the keywords ovarian failure, infertility, and umbilical cord-derived mesenchymal stem cells in the electronic databases Scopus, PubMed, Google scholar, and Web of Science. Also, using the keywords of the desired study, 99 articles were obtained, and considering the intended purpose and removing duplicate articles, 48 articles were obtained.
Results: There are significant effects on mental and physical health in people facing the challenges of premature ovarian failure. The use of hormonal therapies is usually used to reduce the symptoms of estrogen deficiency in women with POF, but it is not very successful. Therefore, there is a need for better treatment options to solve this problem and much research has been conducted to find more effective solutions for the treatment of POF. As a result of numerous studies on the use of umbilical cord-derived mesenchymal stem cells in the treatment of premature ovarian failure, it seems that these cells can play an important role in improving and restoring ovarian function. Among the important results of this research, we can mention the increase in the number and function of follicles, the improvement of the proliferation process, and the regular regulation of hormones. These cells seem to be able to restore ovarian function after damage caused by various things, including chemotherapy. Overall, it appears that umbilical cord-derived mesenchymal stem cells have the potential to improve and repair ovaries in the face of premature ovarian failure. These results suggest that the use of these cells may be an effective and novel approach to treating this deficiency in egg production, improving ovarian function and increasing fertility opportunities in individuals with premature ovarian failure.
Conclusion: One of the ways to treat POF is the use of mesenchymal stem cells derived from the umbilical cord, these cells have an extraordinary capacity for repair and regeneration, which helps them in repairing depleted ovaries. The results of this review article indicate that the use of HUC-MSCs can be considered as a potential treatment method in these patients.