مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Diosmetin trough increase in the CA3 diameter of the hippocampus possessed antidepressant-like effect in mice: possible role of NMDA receptors
Diosmetin trough increase in the CA3 diameter of the hippocampus possessed antidepressant-like effect in mice: possible role of NMDA receptors
Muhammad Awais Ali,1Maryam Anjomshoa,2,*Hossein Amini-Khoe,3Shakiba Nasiri Boroujeni,4Payam Molavi,5-----,6
1. Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran 2. Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran 3. Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran 4. Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran 5. Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
Introduction: The aim was to determine the role of NMDA receptors in the antidepressant-like effects of diosmetin.
Methods: Mice received diosmetin, an NMDA agonist, an NMDA antagonist (ketamine), and combinations. The FST, TST, and OFT were used.
Results: Diosmetin decreased immobility time and augmented CA3 diameter. Ketamine potentiated while NMDA attenuated these effects
Conclusion: Diosmetin exerted an antidepressant-like effect, mediated partly by NMDA receptors and a neuroprotective effect on the hippocampus.