مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Association of Rare SNPs in Vitamin B12 Metabolism Genes with Gastric Cancer Risk in a Nutritionally Deficient Population
Association of Rare SNPs in Vitamin B12 Metabolism Genes with Gastric Cancer Risk in a Nutritionally Deficient Population
Dr. Ghazaleh Eslamian,1Yasaman Pouryousefi,2,*Dr. Majid MesgarTehrani,3Dariush Noroozian,4
1. Assistant Professor Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences Tehran, Iran 2. Shahid Beheshti University of Medical Sciences 3. Member of the Core Committee of the National Genomics Hub, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Introduction: This study investigates the association of rare SNPs in vitamin B12 metabolism genes with gastric cancer risk in nutritionally deficient populations. Considering that stomach cancer is most prevalent in Asia and ranks first among all cancers in Iran, exploring the underlying mechanisms is essential, particularly given the widespread unhealthy dietary practices.
Methods: Data were retrieved from the NCBI (National Center for Biotechnology Information) database, and reference SNPs involved in vitamin B12 metabolism were selected. Polymorphism data analysis and the identification of potential adverse effects with a genetic basis were performed using the pharmacogenomic tool MegaGene.
Results: Among all the polymorphisms analyzed in this study RS1801133 (MTHFR) showed the strongest association with gastric cancer risk. RS80358978 (BRCA2), RS3733890 (BHMT), RS55996097 (BRCA2 STOP GAINED), RS492602 and RS602662 (FUT2), RS2195239 (IGF1), RS11655505 (NBR2), RS5226934 (TCN1), and RS35009941 (TXNRD1) were also found to be highly associated with gastric cancer susceptibility.
Conclusion: Genetic testing to detect polymorphisms in common genes, including ATM, CDH1, BRCA1, BRCA2, and TP53, is performed in patients to assess gastric cancer susceptibility.