Introduction: Indomethacin is a widely used nonsteroidal anti-inflammatory drug (NSAID) for musculoskeletal conditions. While some NSAIDs have been linked to glycemic dysregulation, indomethacin is generally not recognized as a contributor to hyperglycemia. Understanding potential glycemic effects of commonly prescribed drug is critical in managing patients with diabetes mellitus, especially those on stable glucose-lowering regimens.
Methods: A 45-years-old male with well-controlled type 2 diabetes mellitus (T2DM) on oral hypo glycemics and a stable low-carbohydrate diet presented with polyuria after taking oral Indomethacin (25 mg BID for 6 days) for trigger finger. Laboratory analysis showed an acute but moderate increase in fasting blood glucose levels. there was no hepatic or renal impairment. Blood glucose returned to baseline within 72 hours after discontinuation of Indomethacin.
Results: Following the discontinuation of Indomethacin, the patient's blood glucose levels gradually returned to his usual range without any intervention or medication adjustment. The polyuria also resolved. This temporal relationship suggests a possible reversible effect of Indomethacin on glucose metabolism.
Conclusion: This case highlights a potential yet underrecognized glycemic side effect of Indomethacin in diabetic patients. Clinicians should remain vigilant when prescribing NSAIDs to individuals with diabetes, even those with stable glycemic control, and consider monitoring blood glucose levels during treatment.
Keywords: Indomethacin, Hyperglycemia, Type 2 Diabetes, NSAIDs, Case Report