Introduction: This comprehensive review explores recent advancements in transdermal drug delivery systems, focusing on drug-in-adhesive patches. The manuscript discusses various aspects of patch design, including adhesive materials, penetration enhancers, and novel formulation strategies.
Methods: The review examines several key areas: It highlights the development of new pressure-sensitive adhesives (PSAs), such as acrylic-based and hydrogel-based materials, which offer improved skin adhesion and drug compatibility. The review also examines innovative approaches to enhance drug permeation, including the use of chemical penetration enhancers and ionic liquids. Additionally, it addresses challenges in patch formulation, such as drug crystallization and release kinetics.
Results: The manuscript emphasizes the importance of understanding the molecular state of active pharmaceutical ingredients within the patch matrix for optimizing drug delivery efficiency.
Conclusion: Overall, this review provides a thorough overview of current research and future directions in transdermal patch technology, highlighting its potential to improve drug efficacy and patient compliance across various therapeutic areas.
Keywords: Transdermal drug delivery, Drug-in-adhesive patches, Pressure-sensitive adhesives (PSAs)