مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Super-Enhancer-Driven Network Identifies MIR4461 and MIR1204 Regulators in Metastatic Prostate Cancer.
Super-Enhancer-Driven Network Identifies MIR4461 and MIR1204 Regulators in Metastatic Prostate Cancer.
Maria Mahmoudi,1,*Mehrnaz Mousavi,2
1. Department of Molecular Genetics, Faculty of Science, Azad University of Kazerun, Shiraz, Iran 2. Department of Molecular Genetics, Faculty of Science, Azad University of Kazerun, Shiraz, Iran
Introduction: Super-enhancers are large clusters of regulatory elements bound by bromodomain proteins. BET inhibitors block the interaction between BRD4 and these super-enhancers, resulting in suppression of oncogene transcription
Methods: This study combines transcriptomic data from JQ1-treated prostate cancer cell lines and clinical mCRPC samples to identify super-enhancer-regulated gene networks
Results: Functional enrichment analysis was performed pinpointed central hub genes within the SE-DEG nerwork
Conclusion: We present a systems biology framework that identifies MIR1204 and MIR4461 in a super-enhancer-regulated network driving prostate cancer metastasis