• The genetic and epigenetic impact of nutrition on cancer
  • Dr. Ghazaleh Eslamian,1,* Hossein Jamshidi Gilani,2 Dr. Majid Mesgar Tehrani,3
    1. Assistant Professor Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences Tehran, Iran
    2. Genomics Laboratory
    3. Member of the Core Committee of the National Genomics Hub, Shahid Beheshti University of Medical Sciences, Tehran, Iran


  • Introduction: Single nucleotide polymorphisms (SNPs) are the most common genetic variations influencing disease susceptibility and treatment response. This study examined their clinical significance, stressing the value of genetic screening in improving therapy and reducing adverse effects.
  • Methods: Data were retrieved from the NCBI database and analyzed with the pharmacogenetic software “MegaGen” to identify polymorphisms and genetic side effects in a population of over 5,500 individuals.
  • Results: Three SNPs—RS3755967, rs17467825, and rs11668820—showed the strongest disease associations (prevalence 49–98%), with one-third of studies confirming relevance.
  • Conclusion: Genetic testing for common SNPs supports early diagnosis and personalized treatment.
  • Keywords: Polymorphism, SNP, Pharmacogenetics, NCBI, Adverse effects