• Green Synthesis of Nanoparticles by Laser Ablation
  • Asena Asadi,1,* Zahra Zaghari,2 Hasti Roshani,3
    1. Researcher at the Iran Research Club, Karaj.
    2. Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
    3. Researcher at the Iran Research Club, Karaj.


  • Introduction: Laser Ablation in Liquids (LAL) is a rapidly advancing, single-step technique for synthesizing high-purity nanoparticles (NPs). The conventional LAL method uses a pure metal target submerged in a pure solvent (e.g., deionized water). A pulsed laser beam is focused onto the target, causing the ablation of material that subsequently nucleates and forms a colloidal solution of NPs in the surrounding liquid. The "green" synthesis approach modifies this process by replacing the pure solvent with a natural extract or biologically benign liquid. Plant extracts (e.g., from leaves, fruits, or roots) are commonly used as the ablation medium.
  • Methods: Key Advantages of this Green LAL Method: Eco-friendly and Sustainable: Eliminates the need for toxic chemical reducing and stabilizing agents. The natural extract acts as both the solvent and a capping agent. Enhanced Stability: The phytochemicals (like flavonoids, polyphenols, and terpenoids) present in the extract naturally cap the nanoparticles, preventing aggregation and ensuring long-term colloidal stability. Reduced Toxicity: The resulting NPs are often more biocompatible, making them suitable for biomedical applications such as drug delivery, bioimaging, and antimicrobial agents. Dual-Function Synthesis: The process combines the physical ablation of the target material with the immediate biological functionalization of the NP surface by the extract components. Control over Properties: Nanoparticle characteristics like size, shape, and composition can be tuned by varying laser parameters (wavelength, pulse duration, fluence) and the type/concentration of the natural extract used.
  • Results: The goal of this research is to design and optimize a simple laser ablation system capable of producing nanoparticles with controlled size, morphology, and chemical composition. With the growing demand in medicine and life sciences for high-quality nanoparticles featuring precise purity and crystal structure, the shortcomings of chemical methods highlight the need for alternative approaches. Laser-based synthesis not only addresses these challenges but also contributes to the development of indigenous technical knowledge, reducing reliance on imported technologies in nanomaterial production.
  • Conclusion: In conclusion, the integration of natural extracts into the LAL process provides a powerful, environmentally benign route for producing functional, stable, and biocompatible nanoparticles, aligning with the principles of green chemistry and expanding their potential in various technological fields.
  • Keywords: Green Synthesis, Nanoparticles, Laser Ablation in Liquids ,Medical.