Introduction: Herbal medicine is considered a valuable source to support traditional medicine. There are a number of herbs that can be used in conjunction with modern medicine. In addition, some herbs may support recovery from serious diseases. Although cardiovascular disorders should not be treated solely with herbal medicine, the value of herbs used alongside modern medicine cannot be ignored. Saffron has been reported to reduce Cholesterol levels and help maintain healthy lipid profiles. Some studies have shown that the people of Mediterranean countries, where Saffron consumption is common, have a lower incidence of heart diseases.
In this study, the beneficial effects of Chitosan–Saffron nanoparticles on heart failure and cardiovascular health were investigated.
Methods: Nanoparticles were formed by Ionic Gelation method and the formation of appropriate nanoparticles was examined by Scanning Electron Microscopy and Dynamic Light Scattering methods. In addition, by using in vitro anti-inflammatory activity methods such as Albumin Denaturation Assay in different concentrations, the anti-inflammatory effect of Chitosan nanoparticles loaded with extracts of Saffron was investigated. Finally, anticholesterol activity was measured in-vitro by the Cholesterol enzymatic endpoint method using Simvastatin as a positive control.
Results: This article was found that Chitosan–Saffron nanoparticles were able to reduce Cholesterol levels by up to 50%. These nanoparticles also exhibit antioxidant properties that help maintain the integrity of arteries and blood vessels. Furthermore, with their anti-inflammatory activity, they are beneficial for cardiovascular health.
Conclusion: Therefore, these nanoparticles can be considered as a potential supplement to promote heart health.