• Evaluation of Polyurethane nanofibers treated with Cold Atmospheric Plasma for tissue engineering
  • Faezeh Esmaeili Ranjbar,1,* Afsaneh Esmaeili Ranjbar,2
    1. Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
    2. Emergency Medicine Department, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


  • Introduction: Polyurethane (PU) is polymer valued for their excellent mechanical properties, including durability, flexibility, and abrasion resistance, as well as their biocompatibility, light weight, and ease of finishing. The favorable properties of polyurethane (PU) make them common in diverse fields, ranging from industrial products like adhesives and coatings to medical devices such as catheters and orthopedic implants. Nevertheless, as a result of their hydrophobic nature and low surface energy, PU-based scaffolds are not ideal for tissue engineering, as these properties inhibit cell adhesion and proliferation.
  • Methods: This research involved the fabrication of polyurethane (PU) nanofibrous scaffolds (15% w/v) via electrospinning. To enhance their surface properties, the scaffolds were modified with cold atmospheric plasma (CAP) for 10 minutes, and the impact of this treatment on morphology, wettability, and biological performance were assessed.
  • Results: Matrices formed with PU were highly porous with interconnected structures, and the average diameters of PU were about 348.6 ± 10 nm. The SEM results showed that, PU nanofibers which treated10 min by CAP, were melted and aggregated. Moreover, NIH3T3 cell adherence on treated PU was improved after 5 days incubation. Based on our results wettability of our nanofibers increased after treatment.
  • Conclusion: According our results, the manufactured scaffolds are biocompatible, bio adhesive and hydrophilic, which appropriate for tissue engineering.
  • Keywords: Tissue engineering, CAP, PU, Nanofiber