مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Communication between cells in the microenvironment of atherosclerotic plaques
Communication between cells in the microenvironment of atherosclerotic plaques
Nafiseh Shokri,1,*
1. Shahid Beheshti University of Medical Sciences
Introduction: Atherosclerosis develops as a result of numerous cellular and molecular activities within the vessel. It is well understood that as this process progresses, macrophages and vascular smooth muscle cells (VSMCs) polarize and, along with extracellular matrix (ECM) components, contribute to the formation of the central core of atherosclerotic plaque in the media. Furthermore, blood cell recruitment into the subendothelial region and plaque remodeling are microenvironmental activities. This review covers the molecular and cellular events that occur during the atherosclerosis process, as well as the signaling pathways involved in cellular polarization and crosstalk in the vessel subendothelial region.
Methods: This is a narrative review based on major and important articles.
Results: Knowing the molecular alterations and cellular activities in the sub-endothelial milieu during plaque formation will help us understand vascular stenosis.
Conclusion: Atherosclerosis is a multi-faceted, slowly progressing condition. It is caused by various pathological alterations, including disruptions of cell and molecular activities in the vessel's subendothelial region. The atherosclerotic plaques have a cholesterol-rich core and a fibrous top. Furthermore, acquired and innate immunological agents contribute to the progression of plaque. The erosion and rupture of plaques narrows the arteries, slowing blood flow and causing deadly ischemia in the vessels.