مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
The Role of the Gut Microbiome and Probiotics in Colorectal Cancer: A Step Toward Early Diagnosis
The Role of the Gut Microbiome and Probiotics in Colorectal Cancer: A Step Toward Early Diagnosis
Eliya Norouzi,1Sara Sardashti,2Yasna Azizpour,3,*
1. Department of Biology, SR.C., Islamic Azad University, Tehran, Iran. 2. Department of Biology, SR.C., Islamic Azad University, Tehran, Iran. 3. Department of Biology, SR.C., Islamic Azad University, Tehran, Iran.
Introduction: Background:
Colorectal cancer (CRC) remains a major contributor to cancer-related mortality worldwide. Recent research emphasizes the gut microbiome’s critical role in CRC pathogenesis.
Objectives:
This review aims to explore the relationship between gut dysbiosis, probiotics, and CRC, with a particular focus on early diagnosis.
Methods: Methods:
A narrative review was performed using PubMed, Scopus, and Google Scholar databases. Studies on microbiome composition, dysbiosis, probiotics, and biomarkers related to CRC were selected.
Results: Results:
Dysbiosis is consistently associated with CRC development through inflammation and genotoxicity. Probiotics, particularly when combined with prebiotics, demonstrate protective effects by maintaining gut barrier integrity and suppressing pathogenic bacteria. Additionally, microbial biomarkers offer promise for improving early CRC detection.
Conclusion: Conclusion:
Microbiota-targeted therapies and microbial signatures could revolutionize CRC prevention and early diagnosis. However, further clinical validation is necessary.
Keywords: Keywords:
Colorectal cancer, Gut microbiome, Probiotics, Dysbiosis,, Early diagnosis