مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Injectable Nanocosmetics: Design of Smart Nanoparticle-Based Fillers for Skin Rejuvenation, Anti-Aging, and Regeneration with a Precision and Translational Medicine Approach
Injectable Nanocosmetics: Design of Smart Nanoparticle-Based Fillers for Skin Rejuvenation, Anti-Aging, and Regeneration with a Precision and Translational Medicine Approach
Sahar Masoomi,1,*Kourosh Khayam Abed,2
1. Researcher in Medical Genetics, Pharmacogenomics, Pharmaceutical Biotechnology, Nanocosmetics, Nanomedicine, and Applied Artificial Intelligence in Aesthetic Medicine 2. Undergraduate Student in Biotechnology, Naqsh-e Jahan University, Isfahan, Iran
Introduction: In recent decades, the field of aesthetic medicine has witnessed remarkable advances in injectable skin therapies. Approaches such as dermal fillers, botulinum toxin (BTX), and platelet-rich plasma (PRP) have been recognized as primary tools for skin rejuvenation and soft tissue restoration. However, the emerging frontier of injectable nanocosmetics, particularly the design of smart nanoparticle-based fillers, provides a new paradigm for enhancing efficacy, precision targeting, and stimulation of cellular regeneration, establishing its position at the forefront of both scientific and translational applications.
Nanoparticles, as drug and molecular carriers, offer targeted delivery to deep skin layers due to their small size, high surface area, and tunable properties. These features enable injectable fillers not only to provide immediate volumizing effects but also to actively promote collagen regeneration and tissue repair over time. For instance, a recent study by Cheng et al. (2025) demonstrated that a co-crosslinked hydrogel composed of hyaluronic acid (HA) and silk fibroin (SF) merges HA’s rapid filling properties with SF’s collagen-stimulating capabilities, enhancing type III collagen regeneration in UVB-induced photoaged skin. This dual-function approach exemplifies the integration of nanotechnology with translational medicine, bridging the gap from bench to clinic.
A key advantage of nanoparticle-based fillers lies in their multidimensional nature. These systems can be formulated from diverse biomaterials, including lipid-based, polymeric, and metallic nanoparticles, and can precisely influence cellular mechanisms and the extracellular matrix (ECM). Moreover, advanced artificial intelligence (AI) tools enable precision dermatology, allowing personalized therapeutic responses to be optimized predictively. These characteristics differentiate smart fillers from conventional market products, such as creams and serums, positioning them as highly research-oriented and innovative interventions.
From a clinical and regulatory perspective, nanoparticle-based fillers require thorough safety and efficacy assessments due to their direct interaction with skin structures. This scrutiny not only increases confidence among clinicians and patients but also provides translatable data for clinical applications, making such products highly valuable for scientific conferences and translational research. Therefore, the design and development of smart nanoparticle-based fillers represent a convergence of basic research, materials engineering, and translational medicine, promising a new generation of anti-aging and regenerative therapies that surpass the capabilities of conventional market offerings.
In this article, we review the principles underlying injectable nanocosmetic design, focusing on the physicochemical characteristics of nanoparticles, cellular and molecular mechanisms relevant to skin regeneration, the role of bioactive compounds such as hyaluronic acid and natural proteins, and the clinical and regulatory landscape. This comprehensive synthesis, grounded in the latest scientific evidence and pioneering studies, provides a robust framework for the development of smart nanoparticle-based fillers that could set new standards in aesthetic medicine.
Methods: This review analyzed injectable nanoparticle-based fillers for skin rejuvenation, anti-aging, and regeneration. Studies from 2018–2025 were sourced from PubMed, Scopus, Web of Science, and ScienceDirect. Inclusion criteria encompassed nanoparticle types (lipid, polymer, metallic), dermal delivery, ECM and cellular interactions, translational studies, and AI-guided precision dermatology. Data extracted included physicochemical properties, biocompatibility, collagen stimulation, degradation kinetics, tissue integration, and clinical translatability.
Results: Smart injectable nanoparticle-based fillers demonstrated superior skin penetration compared to conventional hydrogels, enabling controlled release of active compounds such as hyaluronic acid (HA), silk fibroin (SF), phytochemicals, and antioxidants. These multifunctional nanoparticles—including lipidic, polymeric, and metallic carriers—enhanced extracellular matrix (ECM) regeneration, fibroblast proliferation, and type III collagen deposition, supporting both immediate volumization and gradual tissue restoration.
Lipidic and polymeric nanoparticles ensured compound stability and minimized degradation, whereas metallic nanoparticles provided additional antioxidant and photoprotective benefits. Targeted delivery via nanoparticles significantly reduced systemic exposure and minimized adverse effects. Furthermore, intelligent design leveraging AI data enabled precision dermatology strategies and personalized treatments. In vitro and in vivo assessments demonstrated favorable safety profiles and effective tissue integration, highlighting clinical translatability.
Conclusion: Smart injectable nanoparticle-based fillers provide a convergent platform integrating immediate volumization, anti-aging activity, and tissue regenerative potential. By combining multi-material design, controlled release, targeted delivery, and multi-level cellular effects, these fillers surpass conventional topical formulations and hydrogels. This approach exemplifies advanced translational dermatology, bridging nanotechnology, biomaterials science, and precision medicine. Future development should focus on clinical trials, AI-assisted personalization, and regulatory adaptation to establish these fillers as next-generation therapeutics in aesthetic medicine.