Introduction: Cervical cancer, which ranks fourth among cancers, is one of the most common and deadly cancers in women."
According to data from the American Cancer Society, the number of people diagnosed with uterine cancer will increase by 1.5% per year from 2013 to 2022.
The highest prevalence of cervical cancer is in China, Russia, and the United States. The most common symptoms that cause cervical cancer are:
One of its symptoms could be HIV because HIV causes and increases the human papillomavirusHexokinase 2 causes tumorigenesis in cells if it phosphorylates glucose to glucose-6The data indicate that circCDKN2B-AS1 facilitates aerobic glycolysis by sponging the IMP3 protein to stabilize HK2 mRNA, consequently promoting the malignant phenotype in cervical cancer. Circular RNAs (circRNAs) play key roles in the development of various types of cancer. However, the biological functions and clinical significance of most circRNAs remain unclear."(Zhang, Zhao et al. 2020)
Cervical cancer is one of the most common female malignancies worldwide, a hypoxic microenvironment usually causes enhanced viability and glycolytic capacity of cervical cancer cells. The aim of this study was to investigate the association between chaperonin containing t-complex polypeptide 1 subunit 6A (CCT6A) and cell proliferation as well as hypoxic glycolysis.
Bioinformatics analysis was conducted to explore the association between cervical cancer and its partner protein under hypoxic conditions, namely, CCT6A. Subsequently, the expression of CCT6A was silenced, and the effects of CCT6A silencing on cervical cancer cell proliferation, cell cycle, glycolysis-related proteins, and telomerase activity were examined.
Materials, setting, methods: Bioinformatics analysis was performed to investigate the expression of CCT6A in cervical cancer under hypoxic conditions. The expression of CCT6A was silenced in cervical cancer cells, HeLa and SiHa, to study its effects on cell proliferation and hypoxic glycolysis. The localization of telomerase activity-related proteins, telomerase CTAB1 and TERT, was detected using immunofluorescence, and their interaction was assessed using immunoprecipitation. A cellular hypoxia model was established, and the products of the glycolysis reaction were detected. A nude mouse tumor model was constructed, and the changes in glycolysis-related proteins in tumor tissues were examined using Western blot, while Ki67 expression in tumor tissues was evaluated by immunohistochemistry.
Telomerase activity was found to be enhanced in CCT6A-silenced cervical cancer cells, along with an increase in telomerase TCAB1 and TERT protein binding associated with telomerase activity. Additionally, the proportion of cells in the Gap 2/mitosis (G2/M) stage and the 5-ethynyl-2'-deoxyuridine (EdU) positivity rate were decreased in CCT6A-silenced cells, indicating a reduction in cell proliferation. The expression of cell cycle-related proteins, including cyclin E, CCNA2, and cyclin-dependent kinase 2 (CDK2), was suppressed. Furthermore, under a hypoxic environment, silencing CCT6A led to a significant reduction in cell viability and downregulation of glycolysis-related proteins, such as lactate dehydrogenase A (LDHA) and hexokinase 2 (HK2). Mechanistically, silencing CCT6A may reduce telomerase activity by inhibiting the TCAB1/TERT interaction. Additionally, TERT was found to activate the promoter region of the HK2 gene, and inhibition of TERT activity reduced the transcriptional level of HK2
Uterine fibroids (UFs) are the most common benign tumors of female genital diseases, unlike uterine leiomyosarcoma (LMS), a rare and aggressive uterine cancer. This narrative review aims to discuss the biology and diagnosis of LMS and, at the same time, their differential diagnosis, in order to distinguish the biological and molecular origins. The authors performed a Medline and PubMed search for the years 1990-2022 using a combination of keywords on the topics to highlight the many genes and proteins involved in the pathogenesis of LMS. The mutation of these genes, in addition to the altered expression and functions of their enzymes, are potentially biomarkers of uterine LMS. Thus, the use of this molecular and protein information could favor differential diagnosis and personalized therapy based on the molecular characteristics of LMS tissue, leading to timely diagnoses and potential better outcomes for patients
Methods: The SIGLANIG MAPK/AMPK/mTOR/S6 identification path was carried out using mega gene software, as well as with the help of ncbi and protein bank databases, as well as Google Scholar.
Results: Based on studies, we draw conclusions ,
In this article we present a better
solution for the treatment of cervical
cancer, namely the use of monoclonal
antibodies, which is better and more
complete than chemotherapy in(c1p5)
and (tvg701y) treatments because in
these two treatments, which cause the
deposition of complement (a group of
plasma proteins produced in the liver
that act to help destroy pathogens),
and this abnormality in complement
system proteins increases infection in
the body or increases the activity of
autoimmune disease, but with
monoclonal antibodies that stimulate
the immune response and are anti
(HPV) (E6) and (E7) as well as not
associated with sediment formation
this is a better and more attractive
solution for It's the destruction of
cancer cells.
Conclusion: Cervical cancer is a serious and dangerous disease among women, where early diagnosis and timely treatment play a vital role in improving quality of life and increasing recovery rates. Prevention through vaccination, regular screening, and raising public awareness about symptoms and risk factors can significantly reduce the burden of this disease. Further research to improve treatment methods and identify new strategies for better controlling cervical cancer is essential
Keywords: If there were a specific type
of protein and plasma in chemotherapy that
would destroy the pathoge