مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Epigenetic biomarkers in aging and longevity: Current and future application
Epigenetic biomarkers in aging and longevity: Current and future application
Mehran Izadi,1Nariman Sadri,2Amirhossein Abdi,3Sahar Serajian,4Dorsa Jalaei,5Safa Tahmasebi,6,*
1. Department of Research & Technology, Zeenome Longevity Research Institute, Tehran, Iran 2. Department of Research & Technology, Zeenome Longevity Research Institute, Tehran, Iran 3. Department of Research & Technology, Zeenome Longevity Research Institute, Tehran, Iran 4. Department of Research & Technology, Zeenome Longevity Research Institute, Tehran, Iran 5. Department of Research & Technology, Zeenome Longevity Research Institute, Tehran, Iran 6. Department of Research & Technology, Zeenome Longevity Research Institute, Tehran, Iran
Introduction: Aging is shaped by genetic, epigenetic, molecular, and environmental factors. Among aging hallmarks, epigenetic alterations such as DNA methylation, histone modifications, chromatin remodeling, and noncoding RNAs are highly conserved and crucial for gene regulation. Understanding their role is essential to reveal mechanisms of aging and design diagnostic, preventive, and therapeutic strategies.
Methods: A narrative review approach focusing on the most recent literature related to epigenomic mechanisms in aging. Identification and critical analysis of studies exploring diagnostic biomarkers, molecular regulators, and therapeutic strategies aimed at reversing epigenetic alterations.
Results: Evidence shows that epigenetic alterations are tightly linked to aging and age-related diseases. DNA methylation clocks and extracellular RNAs emerge as promising biomarkers for assessing biological age. Studies suggest that targeting these pathways may help delay aging processes, improve healthspan, and possibly reverse harmful age-related changes.
Conclusion: Epigenomic changes are central to aging biology and represent valuable tools for diagnosis and intervention. Recognizing their regulators and mechanisms provides opportunities for developing strategies to promote healthy lifespan and prevent age-related decline. Future research should integrate biomarkers into clinical practice for effective aging management.