• Application of nanotechnology-based transdermal patches in targeted drug delivery for cancer treatment
  • Helia Pourhashem,1,* Zahra Zaghari,2
    1. Molla Sadra High School, Karaj
    2. Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.


  • Introduction: Cancer, as one of the leading causes of death in the world, especially in developing countries such as Iran, has created numerous therapeutic challenges, including severe side effects of common methods such as systemic chemotherapy. Therefore, the development of new drug delivery methods with the aim of increasing effectiveness and reducing complications is an undeniable necessity. Objectives: The main objective of this study is to investigate the feasibility and scientific analysis of the use of nanocarrier transdermal patches as a non-invasive method for local treatment of breast cancer, focusing on increasing the effectiveness of the drug in the target tissue and reducing the systemic complications of chemotherapy.
  • Methods: This study was conducted using a library method and a systematic review of previous research in the field of transdermal drug delivery, nanotechnology, and cancer treatment. Also, the laboratory method of making the patch by solvent casting technique using PVA and HPMC polymers and adding plasticizer (glycerol) and drug (such as doxorubicin) is described.
  • Results: The findings show that transdermal patches, especially the advanced generations containing nanocarriers (liposomes, nanoparticles) and penetration enhancement technologies (such as microneedles), have significant advantages: · Reduced systemic side effects by bypassing hepatic and first-pass metabolism. · Increased bioavailability and local targeting of the drug in tumor tissue. · Controlled and sustained drug release leading to stable blood levels and improved patient compliance. · Promising application in the treatment of localized cancers such as breast, skin, and prostate, as demonstrated in clinical studies with drugs such as estradiol, fentanyl, and 5 FU.
  • Conclusion: Transdermal patches, as a promising technology, have the potential to revolutionize anticancer drug delivery. Despite challenges such as limited skin penetration for high molecular weight drugs and production costs, the possibility of localizing this technology in Iran is considered quite feasible given the scientific capacities and infrastructures available in the fields of nano and pharmaceuticals. Combining this technology with targeted and intelligent therapies outlines a bright future for providing personalized solutions in cancer treatment.
  • Keywords: transdermal drug delivery, anticancer patch, nanotechnology, controlled drug release.