مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Diabetic Foot Ulcer Healing Using Maggot Therapy in Hospitalized Patients
Diabetic Foot Ulcer Healing Using Maggot Therapy in Hospitalized Patients
Fatemeh Kourkinejad_Gharaei,1,*Reza Razzaghi,2Taha Tabanfar,3Mansoureh Momen_Haravi,4Mohammad Javad Azadchehr,5Mohammad Kourkinejad,6
1. Department of Infectious diseases, Samen Hospital, Sirjan School of Medical Sciences, Sirjan, Iran 2. Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran 3. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran 5. Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
Introduction: Introduction: Diabetic foot ulcer is a serious complication of diabetes that can lead to prolonged hospitalization and amputation. Maggot debridement therapy (MDT) is a biological debridement method that has been proposed as an option for healing these ulcers. The aim of this study was to compare the healing rate of diabetic foot ulcers using MDT versus standard therapy.
Methods: Methods: This retrospective cohort study was conducted on the medical records of 50 patients with diabetic foot ulcers hospitalized at Shahid Beheshti Hospital in Kashan between 2023 and 2024. Patients were divided into two groups: MDT (n=25) and standard therapy (n=25). Demographic data, wound characteristics, inflammatory laboratory markers (WBC, PMN, ESR, CRP), length of hospital stay, and the need for other interventions (debridement or amputation) were extracted. Data were analyzed using appropriate statistical tests and ANCOVA in SPSS software.
Results: Results: The healing rate was higher in the MDT group (72%) compared to the standard therapy group (56%), but this difference was not statistically significant (p=0.135). No significant difference was observed between the two groups regarding changes in inflammatory markers post-intervention (p>0.05). The mean length of hospital stay was significantly longer in the MDT group (25.00 days) compared to the standard therapy group (18.76 days) (p=0.037).
Conclusion: Conclusion: In this study, MDT did not show a significant advantage over standard therapy in improving systemic inflammatory markers or the final wound healing rate and was associated with a longer hospital stay. Prospective studies with larger sample sizes are required to confirm the clinical benefits of this method.