مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
The Reproductive Microbiome: Implications for Fertility and Assisted Reproduction: A short review
The Reproductive Microbiome: Implications for Fertility and Assisted Reproduction: A short review
Fateme Khodadadi,1,*Haniyeh Aliabadi,2Mojtaba Yousefi,3Amirhossein heidari,4Hossain Mohammad pour Kargar,5
1. Department of Biology, Faculty of Science, Islamic Azad University, Damghan Branch 2. Department of Biology, Faculty of Science, Islamic Azad University, Damghan Branch 3. Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran 4. Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran 5. Department of Biology, Faculty of Science, Islamic Azad University, Damghan Branch
Introduction: The reproductive microbiome has recently emerged as a crucial determinant of fertility and reproductive success. Microbial communities across the vagina, endometrium, gut, and male reproductive tract exert profound effects on gametogenesis, fertilization, implantation, and pregnancy outcomes. . This narrative review summarizes current knowledge on reproductive tract microbiota, their mechanisms of action, methodological challenges, and therapeutic interventions. It also discusses future directions in microbiome-targeted reproductive medicine, highlighting the promise of precision diagnostics and novel treatments such as probiotics, vaginal microbiota transplantation, and multi-omics integration.
Methods: Research records were screened from Embase, Medline, Scopus, and Web of Science. A total of 49 original articles were identified, and genetic, and morphofunctional outcomes were considered.
Results: These studies demonstrated that dominance of Lactobacillus species in vaginal and endometrial niches correlates with positive reproductive outcomes, while dysbiosis is associated with implantation failure, miscarriage, and suboptimal assisted reproductive technology results. Key mechanisms include maintenance of low pH, immune modulation, hormone metabolism, and barrier integrity. Emerging evidence also implicates gut and semen microbiomes in reproductive endocrinology and sperm quality. Therapeutic strategies—probiotics, antibiotics, diet, microbiota transplantation—are being investigated, though methodological challenges persist.
Conclusion: The health and composition of the reproductive tract microbiomes—vaginal, endometrial, gut, and semen—emerge as key determinants of fertility. Therapeutic strategies are evolving but require rigorous validation. Advances in sequencing, modeling, and personalized approaches promise to reshape reproductive medicine.