مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Review of the Relationship Between Diet, Nutrient Intake, and Lifestyle Factors with HPV Infection: A Narrative Review
Review of the Relationship Between Diet, Nutrient Intake, and Lifestyle Factors with HPV Infection: A Narrative Review
Mahshid bokaie,1Azam Zare Arashlouei,2,*
1. PhD of Sexual & Reproductive Health Faculty Member of Nursing and Midwifery Collage Shahid Sadoughi University of Medical Sciences‚ Yazd‚Iran 2. PhD Student Research Committee‚ Faculty of Nursing and Midwifery‚ Shahid Sadoughi University of Medical Sciences‚ Yazd‚ Iran.
Introduction: Human papillomavirus (HPV) is a significant global public health challenge linked to a broad spectrum of cancers, especially cervical cancer. Nutrition plays a critical role in the progression of HPV infection toward carcinogenesis. This review aims to examine the relationship between diet, nutrient intake, and lifestyle factors with HPV infection and its progression to cervical intraepithelial neoplasia (CIN) and cancer
Methods: The present study is a narrative review conducted to gather information on this topic. To collect relevant articles, the researchers performed a computerized search of databases including Google Scholar, PubMed,Web of science, Magiran, and SID covering the period from 2000 to 2025. The search utilized keywords such as human papillomavirus, nutrition, nutrients, and lifestyle. Initially, 27 articles were identified, and their abstracts were screened; studies that did not address the research question were excluded. Subsequently, the full texts of the remaining articles were reviewed, and data from 17 articles were used to develop this review.
Results: This review demonstrates that nutrition and lifestyle play a vital and complex role in the prevention and management of HPV infection and its progression to cervical cancer. Adequate intake of micronutrients such as vitamin K, vitamin A (in appropriate amounts), alpha-lipoic acid, zinc, iron, selenium, folate, vitamin C, and vitamin E can enhance immune function, reduce inflammation, and inhibit the growth of cancer cells.
Healthy dietary patterns, such as the Mediterranean diet and diets rich in fruits, vegetables, and legumes, are associated with a reduced risk of HPV infection and precancerous lesions. Conversely, Western dietary patterns and foods with high glycemic index and load may increase the risk of infection and disease progression. Besides diet, lifestyle factors like regular physical activity also contribute to lowering the risk of HPV infection. In contrast, smoking and alcohol consumption are recognized risk factors that exacerbate HPV infection and cancer progression, and therefore should be avoided.
Conclusion: Adopting a comprehensive approach that promotes balanced, nutrient-rich diets and encourages an active lifestyle free from tobacco use and excessive alcohol consumption can serve as an effective strategy to reduce the global burden of HPV-related diseases.