• Title: Human papilloma virus review article
  • Anahita oboudi,1 Saman hakimian,2,*
    1. Zandunivercity
    2. Phd. student of Microbiology ,Biology department , Islamic Azad University Central Tehran Branch, Tehran , Iran


  • Introduction: Introduction: Human papilloma viruses(HPV) are associated with a spectrum of different diseases in humans including common warts and genital warts of more serious concern is the connection between certain HPv types and some malignancies particularly cervical and anal cancer Human papillomavirus(HPV) infections have received considerable attention in recent years of the 120 or so known types of the virus some cause a variety of benign wart-like lesions of the skin and gential and oral mucosae whilst others are aetiologically associated with cervical and anogenital cancers. Recent epidemiologic evidence suggests that HPV may also be an independent risk factor for oropharyngeal cancer.
  • Methods: Material and methods: In this context it has been suggested that HPV virus may modulate the process of carcinogenesis in some tobacco and alcohol induced oropharyngeal cancers and act as the primary oncogenic agent for inducing carcinogenesis among non-smokers.Infections with human papillomavirus (HPV) are common and transmitted by direct contact. Although the great majority of infections resolve within 2 years, 13 phylogenetically related, sexually transmitted HPV genotypes, notably HP V16, cause-if not controlled immunologically or by screening virtually all cervical cancers worldwide, a large fraction of other anogenital cancers and an increasing proportion of oropharyngeal cancers.
  • Results: Results: Vaccination to prevent human papillomavirus (HPV)-related infection leading to cancer, particularly cervical cancer, is a major public health breakthrough. There are currently two licensed HPV vaccines, both of which contain recombinant virus-like particles of HPV types 16 and 18 (which account for approximately 70 % of cervical cancer). One vaccine also protects against HPV types 6 and 11, which cause genital warts.HPV VLP vaccines have a good safety profile and national and international authorities endorse this.
  • Conclusion: Conclusion: Although the great majority of infections resolve within 2 years, 13 phylogenetically related, sexually transmitted HPV genotypes, notably HP V16, cause-if not controlled immunologically or by screening—virtually all cervical cancers worldwide, a large fraction of other anogenital cancers and an increasing proportion of oropharyngeal cancers.
  • Keywords: HPV Vaccine Virus Cancer Papillomavirus