• The Biological Mechanisms of Chrysin in Bone Regeneration, Density, and Mass Enhancement: A Systematic Review
  • fatemeh shirvani farsani,1 niloofar ghadimi,2,*
    1. Oral and Maxillofacial Resident at Faculty of Dentistry, Isfahan Islamic Azad University, Isfahan, Iran
    2. Oral and Maxillofacial radiology at Faculty of Dentistry, tehran Islamic Azad University, tehran, Iran


  • Introduction: Bone regeneration and remodelling are fundamental processes that ensure the integrity of our skeletal system and are critical for the success of various orthopaedic and dental procedures. Chrysin, a natural plant flavonoid, has shown considerable promise in enhancing bone regeneration, density, and overall skeletal health. By uncovering the biological mechanisms of chrysin, we can explore its potential applications in clinical settings, offering new hope for improved treatment options. This systematic review consolidates research on chrysin, highlighting its effects and significance in promoting bone health.
  • Methods: To provide a comprehensive analysis, we searched multiple key databases, including PubMed, Scopus, and Google Scholar, for studies exploring chrysin's role in promoting bone regeneration and density. We used specific keywords such as "chrysin," "bone regeneration," "bone density," and "flavonoids." Our selection focused on peer-reviewed articles, clinical trials, and preclinical studies that examined chrysin's influence on bone cells and its effects on regeneration and density. We carefully analyzed the data to summarize findings and assess the quality of the research.
  • Results: Our review highlighted numerous studies showing the positive effects of chrysin on bone cell growth, differentiation, and mineralization. Notably, chrysin enhances the activity of osteoblasts, the cells responsible for new bone formation, while inhibiting osteoclasts, which break down bone tissue. This dual action contributes to building stronger bones. Additionally, we found that chrysin affects key biochemical pathways, particularly the Wnt/β-catenin signalling pathway, which is essential for bone development. Its antioxidant properties also promote a healthier environment for bone healing by reducing oxidative stress and inflammation. The evidence suggests that chrysin improves bone density and may help accelerate healing after skeletal injuries or surgeries. Our review highlighted numerous studies showing the positive effects of chrysin on bone cell growth, differentiation, and mineralization. Notably, chrysin enhances the activity of osteoblasts, the cells responsible for new bone formation, while inhibiting osteoclasts, which break down bone tissue. This dual action contributes to building stronger bone . Additionally, we found that chrysin affects key biochemical pathways, particularly the Wnt/β-catenin signaling pathway, which is essential for bone development. Its antioxidant properties also promote a healthier environment for bone healing by reducing oxidative stress and inflammation. The evidence suggests that chrysin improves bone density and may help accelerate healing after skeletal injuries or surgeries.
  • Conclusion: The findings of this systematic review highlight chrysin's promising potential as a therapeutic agent for enhancing bone regeneration and density. By targeting key signalling pathways and offering antioxidant support, chrysin plays a significant role in promoting bone health. As research advances, chrysin could become an important tool in oral and dental practices, improving healing outcomes and better patient care. The findings of this systematic review highlight chrysin's promising potential as a therapeutic agent for enhancing bone regeneration and density. By targeting key signalling pathways and offering antioxidant support, chrysin plays a significant role in promoting bone health. As research advances, chrysin could become an important tool in oral and dental practices, improving healing outcomes and better patient care. The findings of this systematic review highlight chrysin's promising potential as a therapeutic agent for enhancing bone regeneration and density. By targeting key signalling pathways and offering antioxidant support, chrysin plays a significant role in promoting bone health. As research advances, chrysin could become an important tool in oral and dental practices, improving healing outcomes and better patient care. The findings of this systematic review highlight chrysin's promising potential as a therapeutic agent for enhancing bone regeneration and density. By targeting key signalling pathways and offering antioxidant support, chrysin plays a significant role in promoting bone health. As research advances, chrysin could become an important tool in oral and dental practices, improving healing outcomes and better patient care. The findings of this systematic review highlight chrysin's promising potential as a therapeutic agent for enhancing bone regeneration and density. By targeting key signalling pathways and offering antioxidant support, chrysin plays a significant role in promoting bone health. As research advances, chrysin could become an important tool in oral and dental practices, improving healing outcomes and better patient care. The findings of this systematic review highlight chrysin's promising potential as a therapeutic agent for enhancing bone regeneration and density. By targeting key signalling pathways and offering antioxidant support, chrysin plays a significant role in promoting bone health. As research advances, chrysin could become an important tool in oral and dental practices, improving healing outcomes and better patient care. The findings of this systematic review highlight chrysin's promising potential as a therapeutic agent for enhancing bone regeneration and density. By targeting key signalling pathways and offering antioxidant support, chrysin plays a significant role in promoting bone health. As research advances, chrysin could become an important tool in oral and dental practices, improving healing outcomes and better patient care. The findings of this systematic review highlight chrysin's promising potential as a therapeutic agent for enhancing bone regeneration and density. By targeting key signalling pathways and offering antioxidant support, chrysin plays a significant role in promoting bone health. As research advances, chrysin could become an important tool in oral and dental practices, improving healing outcomes and better patient care. The findings of this systematic review highlight chrysin's promising potential as a therapeutic agent for enhancing bone regeneration and density. By targeting key signalling pathways and offering antioxidant support, chrysin plays a significant role in promoting bone health. As research advances, chrysin could become an important tool in oral and dental practices, improving healing outcomes and better patient care. The findings of this systematic review highlight chrysin's promising potential as a therapeutic agent for enhancing bone regeneration and density. By targeting key signalling pathways and offering antioxidant support, chrysin plays a significant role in promoting bone health. As research advances, chrysin could become an important tool in oral and dental practices, improving healing outcomes and better patient care. The findings of this systematic review underscore chrysin's promising potential as a therapeutic agent for enhancing bone regeneration and density. By acting on critical signalling pathways and providing antioxidant support, chrysin plays a significant role in promoting healthy bones. As research continues to evolve, chrysin could become an important tool in oral and dental practices, leading to better healing outcomes and patient care.
  • Keywords: Chrysin, bone regeneration, bone density, osteoblasts, osteoclasts