مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Insight to Streptococcus pneumoniae and Its Relationship with the Antibiotic Streptomycin
Insight to Streptococcus pneumoniae and Its Relationship with the Antibiotic Streptomycin
Mehrasa Zabihi,1Saman Hakimian,2,*
1. Student of Microbiology, Biology department, Islamic Azad University Central Tehran Branch 2. Student of Microbiology, Biology department, Islamic Azad University Central Branch
Introduction: Streptococcus pneumoniae is a Gram-positive, facultative aerobic, lanceolate-shaped bacterium, found in both encapsulated and non-encapsulated forms. More than 100 serotypes exist, with the encapsulated form being the primary
cause of pneumonia, meningitis, otitis media, and bacteremia.
Streptomycin is an aminoglycoside antibiotic that kills bacteria by inhibiting protein synthesis. It is more effective against Gram-negative bacteria, but can also affect some Gram-positive bacteria. In laboratory animals, streptomycin was found to be highly effective against some strains of Streptococcus, although resistant strains have emerged against this drug, particularly compared to other antibiotics
Methods: The prevalence of this disease has undergone significant changes over the years.
In experimental animal studies, streptomycin was able to inhibit infections caused by Streptococcus pneumoniae.
The polysaccharide capsule is the most important virulence factor, providing resistance against phagocytosis
Results: Continuous monitoring of pneumococcal serotypes and antibiotic resistance is necessary to update treatment strategies and vaccination programs.The inflammation caused by pneumococcus is a major factor in clinical symptoms and mortality, and its treatment with antibiotics may worsen the patient’s condition due to increased bacterial lysis.
Drug resistance in Streptococcus can increase hospitalization time and, in some cases, mortality.
Conclusion: The capsule of Streptococcus pneumoniae is the main virulence factor of this bacterium, which causes pneumonia. This polysaccharide layer surrounding the bacterial cell protects it against the host’s defenses. The polysaccharide capsule (CPS) of this bacterium is used as an antigen gene for the production of different vaccine types against invasive pneumococcal diseases (IPD)