مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Insight to the role of probiotics in Controlling Antibiotic – Resistant in the Human Gastrointestinal Tract with Emphasis on Escherichia coli and Enterococcus sp.
Insight to the role of probiotics in Controlling Antibiotic – Resistant in the Human Gastrointestinal Tract with Emphasis on Escherichia coli and Enterococcus sp.
Maryam Makvandi,1Saman Hakimian,2,*
1. M.Sc. Microbiology, Department of Biology, Islamic Azad University, Borujerd Branch, Borujerd, Iran 2. Phd. student of Microbiology ,Biology department , Islamic Azad University Central Tehran Branch, Tehran , Iran
Introduction: Introduction:
The global rise of antibiotic resistance has emerged as a major public health concern, threatening the efficacy of available antimicrobial therapies. Gastrointestinal pathogens such as Escherichia coli and Enterococcus spp. play a significant role in this crisis due to their high ability to acquire and disseminate resistance genes. In particular, extended-spectrum β-lactamase (ESBL)-producing and carbapenem-resistant E.
Methods: Material and methods:
This review synthesized data from previously published studies investigating the role of probiotics in controlling antibiotic-resistant gastrointestinal pathogens. Evidence included in vitro co-culture experiments, animal models, and randomized controlled clinical trials. Sources were drawn from peer-reviewed national and international publications addressing the interaction between probiotics and resistant strains of E. coli and Enterococcus spp. Studies highlighted the mechanisms of action, experimental outcomes, and clinical applications of probiotics against resistant organisms.
Results: Results :
A large number of experimental studies support the antagonistic role of probiotics against resistant gastrointestinal pathogens. In vitro experiments demonstrated that Lactobacillus acidophilus and L. casei reduced the growth of pathogenic E. coli strains, including O157:H7. Similar findings were reported in dairy models, where co-cultivation suppressed proliferation of resistant strains. Animal studies revealed that administration of Lactobacillus rhamnosus GG and other lactobacilli significantly reduced intestinal colonization of VRE.
Conclusion: Conclusion:
Antibiotic resistance in gastrointestinal pathogens, particularly Escherichia coli and Enterococcus spp., poses a major global health challenge. Probiotics represent a promising complementary strategy for mitigating colonization and transmission of resistant organisms. Evidence from in vitro, animal, and clinical studies highlights mechanisms such as competitive exclusion, production of antimicrobial metabolites, and immune modulation.