• Sex-Based Analysis of Common Polymorphisms in Chronic Myeloid Leukemia within the Iranian Genomic Profile and Assessment of Adverse Effects of Domestically-Developed Drugs
  • Majid Mesgartehrani,1,* Anahita Khayati,2 Mohammad Mahdi Eslami,3 Reza Mirlohi,4


  • Introduction: Side effects of drugs are one of the problems in the treatment of patients with CML. The aim of this study is to investigate common polymorphisms in CML in Iranian men and women and the side effects of Iranian drugs on these polymorphisms.
  • Methods: In this study, the NCBI database was used to find common CML polymorphisms. Also, the Megagene pharmacogenetic software was used to analyze polymorphism information and detect side effects of drugs of genetic origin.
  • Results: The results of the study show that some polymorphisms cause side effects of drugs due to consumption.
  • Conclusion: In order to use drugs for the treatment of CML, it is necessary to first perform genetic tests to check the presence of gene polymorphisms in common cases, including DKC1 (rs2728726), BRCA2 (rs80359473), ABCC2 (rs717620) and TGFB1 (rs8179181), on patients, so that if there is a polymorphism, drugs with fewer side effects can be used to treat the patient.
  • Keywords: CML, Pharmacogenomics, SNP, Adverse drug reactions, Iranian population