مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Vericiguat alone and in combination with 17β-estradiol improves lipid profile and oxidant/antioxidant status in obese ovariectomized rats
Vericiguat alone and in combination with 17β-estradiol improves lipid profile and oxidant/antioxidant status in obese ovariectomized rats
Azadeh Shahrokhi Raeini,1,*Mohammad Khaksari Hadad,2Hamideh Bashiri,3Fatemeh Majidpour,4Mahdiyeh Lashkarizadeh,5
1. Department of Physiology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran 2. Department of Physiology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran 3. Neuroscience Research Center, Institute of Neuropharmacology, Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran 4. Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran 5. Pathology and Stem Cell Research Center, Department of Pathology, School of Medicine, Kerman, Iran
Introduction: After menopause disrupt antioxidant balance and lipid profiles, obesity also causes cardiometabolic diseases. Vericiguat restored cGMP. This study investigated effects of estradiol and Vericiguat alone and in combination on lipid and antioxidant profiles in obese ovariectomized rats.
Methods: In this study, female rats were divided into two general groups: sham and OVX. Two weeks after the ovariectomy, the OVX animals received a standard diet (SD)or high-fat diet (HFD) for 4 months. Then, the animals were treated with 17-β estradiol (i.p), and Vericiguat groups received an oral gavage of low (0.3) or high (1) mg/kg/day doses for four weeks.
Results: Ovariectomy resulted in increased serum MDA and decreased TAC levels (P<0.05). HFD consumption in OVX rats increased MDA and decreased TAC compared (P<0.01). Estradiol decreased serum MDA and increased TAC levels (P<0.01). Also, both doses of Vericiguat decreased MDA and increased in TAC levels (P<0.05). In the combined group, the effect was greater than the use of these two drugs alone. Compared to the SD group, HFD consumption resulted in increased serum Chol, LDL, and triglyceride levels and decreased HDL levels (P<0.01). Both doses of Vericiguat decreased serum triglyceride, Chol, and LDL and increased HDL levels (P<0.05). There was no significant difference between Estradiol and Vericiguat. The effects were greater in the combination group compared to the alone groups (P<0.05).
Conclusion: The consumption of Vericiguat and estradiol alone and in combination improves cardiometabolic diseases and oxidative balance in obese OVX rats.