• Investigation of common polymorphisms in BRCA2 gene and the co-occurrence of breast cancer, along with an evaluation of the adverse effects of chemotherapeutic agents.
  • majid mesgar,1 Atousa Mataji Kojori,2,*
    1. tehran, iran
    2. Dentist, Tehran, Iran


  • Introduction: Genetics, particularly BRCA2 and its common SNPs, significantly influence breast cancer risk, severity, and response to chemotherapy.
  • Methods: All single nucleotide polymorphism (SNPs) were collected from NCBI (National Center for Biotechnology Information). The included SNPs were then imported to Mega Gene software for computational analysis, each SNP was analyzed in terms of frequency, incidence rate and their association with the adverse effects of chemotherapeutic agents.
  • Results: In total, 708 SNPs were included in the study. The results showed that most cited SNPs were rs206075, rs80359405 and rs2219594 respectively. However, no significant association was observed between adverse effects of chemotherapeutic agents and common BRCA2 polymorphisms
  • Conclusion: Genetic screening should be considered to evaluate the presence of polymorphisms in common cancer-related genes including BRCA2, in order to facilitate the personalized prescription of appropriate anticancer medications.
  • Keywords: BRCA2 Gene, Breast neoplasms, Poly morphism, Single Nucleotide, Antineoplastic Agents, Drug-Related