مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Investigation into new follicles for the treatment of androgenetic alopecia with stem cells
Investigation into new follicles for the treatment of androgenetic alopecia with stem cells
Maryam Rahmani,1,*
1. Department Of Biology,East Tehran Branch,Islamic Azad Unversity,Tehran,Iran
Introduction: Androgenetic alopecia is one of the most common hair-related disorders, especially in middle-aged men and women. This problem is usually caused by genetic and hormonal influences, particularly the hormone DHT (dihydrotestosterone), which causes hair follicles to shrink and stop growing. This process gradually leads to hair loss and thinning .Common treatments for hair loss include anti-hair loss medications such as finasteride and minoxidil, and surgical procedures such as hair transplants. In recent years, the use of hair follicle stem cells has been considered as a new and sustainable treatment option for hair loss. These cells can help regenerate hair follicles and, in theory, offer a more sustainable and non-surgical treatment for hair loss. This article will review in detail the biological mechanisms of hair follicle stem cells, the challenges and novel methods in activating and using these cells, and analyze their applications in the treatment of hair loss.
Methods: 1. Biological mechanisms and signaling in hair follicle stem cells:Hair follicle stem cells (HFSCs) are located in an area called the bulge at the lower surface of the hair follicle. These cells have the potential to transform into different types of hair follicle cells and can be activated and start producing hair in response to specific signals . One of the most important signaling pathways in the activation of these cells is the Wnt/β-catenin pathway, which plays a fundamental role in the growth and regeneration of hair follicles . Stimulating this pathway can cause stem cell proliferation and the production of new follicles.Studies have shown that chemical compounds such as CHIR99021 and BIO, which are known to be stimulators of the Wnt pathway, can effectively stimulate the activity of hair follicle stem cells and enhance the production of new hair in laboratory models.2. Inhibition of DHT and its role in hair loss:
The hormone DHT is one of the main factors in androgenetic alopecia, which is particularly effective in men. DHT causes hair follicles to shrink and stop growing. Available treatments such as finasteride and dutasteride specifically inhibit the production of DHT and can reduce hair loss. However, these drugs do not directly affect hair follicle stem cells and, therefore, are not able to regenerate new follicles on their own .
According to some studies, combining DHT-inhibiting therapies with stimulation of signaling pathways such as Wnt can help activate hair follicle stem cells and produce new follicles.3. Challenges and limitations in the use of hair follicle stem cell:Although the potential for using hair follicle stem cells to treat hair loss is very promising, there are still challenges in this field. One of the major challenges is how to successfully transplant the stem cells to the scalp.
Studies have shown that transplanting hair follicle stem cells effectively to regenerate new follicles is very challenging . Also, maintaining stem cell activity in vitro and in vivo requires optimization of culture conditions and new technologies.
Results: Recent advances in the use of hair follicle stem cells have shown that these cells can serve as a new and sustainable method for treating hair loss. Research has shown that stimulation of the Wnt/β-catenin pathway and inhibition of DHT can help regenerate new follicles and make hair loss treatment a more permanent process .
Conclusion: Hair follicle stem cells (HFSCs) have great potential as a new treatment for androgenetic alopecia. Stimulation of signaling pathways such as Wnt and inhibition of DHT can help regenerate new follicles and make hair loss treatment a more sustainable and permanent method. However, further research is needed to optimize the conditions for stem cell culture and transplantation and their effective activation in this context.