مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
How do key minerals influence cancer risk and progression?
How do key minerals influence cancer risk and progression?
Hanieh Askari,1,*Pedram Bolouki,2
1. B.sc in Biotechnology, University of Kashan, Kashan, Iran 2. M.sc student of Biochemistry, University of Kashan, Kashan, Iran
Introduction: Various bioactive compounds found in food, such as vitamins and minerals, have been studied for their potential impact on cancer risk. In this abstract, we focus on several crucial minerals, including calcium, magnesium, zinc, iron, selenium, and copper, and investigate their relationship with cancer.
Methods: A balanced diet that is rich in minerals can support overall health and assist in managing cancer.
Calcium can be found abundantly in foods such as milk, preserved fish, white beans, cabbage, and hazelnuts. Magnesium-rich foods include buckwheat, nuts, legumes, cocoa, and seafood. Excellent sources of zinc are dark bread, various types of meat, rennet cheese, liver, and pulses. Selenium is present in a variety of foods, including Brazil nuts, shellfish, poultry, beef, garlic, legumes, and mushrooms. Iron is commonly obtained from foods such as parsley, legumes, and red meat. Foods rich in copper include liver, oysters, sesame seeds, and cocoa.
Results: Calcium is vital for mitotic cell division and chromosome segregation. Also, calcium supplementation may protect against colorectal cancer.
Magnesium is essential for microtubule polymerization. Magnesium deficiency can lead to chromosome segregation abnormalities and carcinogenesis.
Zinc is crucial for forming proteins with "zinc fingers," which play a key role in DNA binding. Insufficient zinc intake can lead to both single and double-strand breaks in DNA and impaired p53 function.
Selenium helps prevent DNA adducts and DNA breaks, as well as changes in chromosomes including mitochondrial DNA.
Iron significantly influences the tumor microenvironment and metastasis. In cancer cells, iron metabolism pathways are altered, emphasizing the need for reprogramming to ensure tumor cell survival.
Copper complexes can influence nuclear activity by interacting with DNA, potentially breaking phosphodiester bonds and destroying tumor cells. They can also penetrate the gaps between base pairs, altering the DNA.
Conclusion: Studies suggest that a combination of ascorbate, lysine, proline, arginine, N-acetylcysteine, selenium, copper, manganese, and calcium may inhibit NF-kB activity in cancer cells.
Higher magnesium intake is linked to a lower risk of all-cause mortality in women with breast cancer.
Selenium is vital for circulating cancer-fighting antioxidants in the body. Selenium binding protein 1 (SBP1) is a prognostic factor in nasopharyngeal carcinoma, breast cancer, and renal cancer.
High iron levels can promote tumor growth while reducing iron intake or using iron chelators can inhibit it.
Copper plays a vital role in angiogenesis. Elevated levels of copper have been linked to various cancers, including breast, colorectal, prostate, brain, and lung cancers.