مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Hsv Infection from epidemology to next-generation therapies
Hsv Infection from epidemology to next-generation therapies
Mahla Bastani,1Saman Hakimian,2,*
1. Bachelor student of pharmacy, Dalian Medical university, Dalian, China 2. phd. student of microbiology, Biology department, Islamic Azad University Centeral Tehran Branch, Tehran, Iran
Introduction: Introduction:
The diagnosis of virus genital herpes is typically challenging because, as we previously discussed, it is frequently asymptomatic and may be imprecise due to its unusual presentation and symptoms that overlap with those of other infections (e.g. G. chancroid, syphilis). Some direct methods of diagnosing this virus include the polymerase chain reaction (PCR), a molecular method that distinguishes via melting cures. It is the best method due to its high sensitivity and ability to detect asymptomatic shedding, but it also has some limitations, including the possibility of contamination (false positive) and the need for specialized equipment.
Methods: Material methods:
Two specific recombinant subunit vaccines have been the subject of extensive double-blind, placebo-controlled clinical trials: Chiron's gB2/gD2/MF59 vaccine: This vaccine, which consists of two HSV-2 glycoproteins, was tested in a large trial but did not demonstrate an overall decrease in the severity of the disease or the acquisition of HSV-2 infection. However, during the first few months of the study, it did demonstrate a brief decrease in acquisition for females. According to a prior study, it lessened the severity of recurring lesions. Moreover, the gD2/AS04 vaccine from GlaxoSmithKline, which contains the gD2 glycoprotein and a particular adjuvant, did not prevent genital herpes in the general study population. It did, however, significantly prevent HSV-2-caused genital herpes in women who were seronegative for both HSV-1 and HSV-2, according to a post-hoc analysis.
Results: Results:
The following are risk factors for HSV-1: sharing cutlery or making contact with the mouth are risk factors for orolabial herpes. A major risk factor for herpes gladiatorum one is participation in certain sports, such as rugby or wrestling. Herpetic whitlow is another type that affects the fingers and is typically observed in children who have thumb-sucking or nail-biting, as well as in medical professionals. Kaposi varicelliform eruption (eczema herpeticum), a severe, widespread HSV infection, is primarily caused by conditions that compromise the skin barrier, such as atopic dermatitis.
Orolabial Herpes: Commonly known as "cold sores." A primary infection can cause painful gingivostomatitis in children or pharyngitis in adults. Recurrent infections are usually milder and appear on the lip's vermillion border.
Conclusion: Conclusion:
Acyclovir is a triphosphate that transforms into its active form, interferes with the viral DNA, and stops it from replicating. It is actually taken orally for mild to moderate illness, but it is administered intravenously for severe, widespread infections like HSV encephalitis. To avoid kidney damage, acyclovir should be administered gradually over the course of an hour. Furthermore, a prodrug that has a higher bioavailability than acyclovir is available.