مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Role of Extracellular Vesicles in Ovarian–Uterine Communication: Emerging Messengers in Female Fertility
Role of Extracellular Vesicles in Ovarian–Uterine Communication: Emerging Messengers in Female Fertility
Anahita Babaei,1Saba Safdarpour,2,*
1. Department of Cellular and Molecular Biology, Faculty of New Sciences and Technologies, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran 2. Department of Cellular and Molecular Biology, Faculty of New Sciences and Technologies, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran
Introduction: Effective communication between the ovary and uterus is fundamental to reproductive success. While endocrine signals have been extensively characterized, extracellular vesicles (EVs) are now recognized as novel mediators of this dialogue.
Methods: A literature search of PubMed, Scopus, and Web of Science was conducted, focusing on studies from the last decade addressing EV-mediated signaling in reproductive biology.
Results: EVs orchestrate ovarian and uterine function through distinct mechanisms. MicroRNA transfer (e.g., miR-21, miR-146a) regulates oocyte maturation, endometrial receptivity, and inflammatory balance. Protein and growth factor delivery (such as TGF-β, VEGF, HSPs) supports folliculogenesis, angiogenesis, and implantation. Lipid-mediated signaling modulates key cascades including PI3K/Akt and MAPK. Importantly, bidirectional EV exchange between ovary and uterus represents a novel regulatory axis that complements hormonal pathways. These mechanisms suggest EVs act as integrative messengers linking follicular development with uterine preparation for implantation.
Conclusion: EVs redefine the paradigm of ovarian–uterine communication by providing a mechanistic bridge that supports fertility. Their potential as biomarkers and therapeutic targets offers promising translational opportunities in reproductive medicine.