مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Nanovesicle-Magnetic Nanoparticle Hybrid Systems for Cancer Targeting and Non-Invasive Imaging
Nanovesicle-Magnetic Nanoparticle Hybrid Systems for Cancer Targeting and Non-Invasive Imaging
Sara Salatin,1,*
1. Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Introduction: Cancer is increasingly acknowledged as a major global health challenge with significant unmet medical needs. Despite advances in anticancer drug development, effective cancer management remains difficult. One key issue is that cancer cells are often hard to detect and treat, complicating efforts to achieve successful outcomes. The combined application of nanovesicles and magnetic nanoparticles is an emerging and promising strategy for cancer targeting and imaging.
Methods: Nanovesicles are small naturally derived or synthetic vesicles capable of carrying therapeutic agents, while magnetic nanoparticles possess unique magnetic properties that allow them to act as contrast agents for imaging techniques like magnetic resonance imaging and can also be used for targeted therapy. When combined, these hybrid systems use the advantages of both carriers for enhanced cancer treatment and diagnosis.
Results: These platforms improve cancer treatment by accumulating specifically in tumor tissues, guided by external magnetic fields. Studies have shown significant tumor targeting and efficient therapeutic effects in various cancer models using nanovesicle-magnetic nanoparticle hybrid systems, including breast cancer and solid tumors. In addition to imaging, magnetic nanovesicles have therapeutic potential through hyperthermia, a process where magnetic nanoparticles generate localized heat when exposed to alternating magnetic fields, inducing cancer cell death or triggering controlled drug release at targeted sites.
Conclusion: The use of nanovesicle-magnetic nanoparticle hybrid systems is now well recognized as a potential theranostic option for improving cancer treatment outcomes and reducing adverse effects. However, despite their promise, challenges such as large-scale production, long-term safety, regulatory approval, and precise control of drug release and hyperthermia effects remain key areas for further research and development.