مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
A Review of Electrochemical Biosensors in Disease and Cancer Detection
A Review of Electrochemical Biosensors in Disease and Cancer Detection
Vida Nikasa,1,*Sedigheh Fekri Aval,2
1. Department of Biology, Tabriz Branch, Islamic Azad University, Tabriz, Iran 2. Department of Biology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Introduction: Introduction: According to Professor Marshal Marinker, illness can be defined as a pathological condition, encompassing both physical and emotional discomfort, which indicates a lack of well-being within an individual.
Different laboratory tests are conducted based on the nature of the illness and the specific area of discomfort experienced by the individual. These tests are recommended by the doctor and may involve blood tests, imaging techniques, and in cases involving genetic disorders, molecular methods. diseases assessed by electrochemical biosensors can be mentioned diabetes, Cardiovascular diseases, Parkinson's disease (PD), Alzheimer's disease (AD) and Multiple sclerosis (MS) are that with quick and accurate identification, it has improved people's lives, especially in the elderly.
According to the World Health Organization (WHO), cancer is a large group of diseases characterized by the uncontrolled growth and spread of abnormal cells. These abnormal cells can invade nearby tissues and spread to other parts of the body through a process called metastasis, which is a major cause of cancer-related deaths. cancer detection methods include the detection of cancer markers with blood tests, which are time-consuming, expensive, and invasive, and other fast and non-invasive but expensive methods such as X-ray, CT-scan, and MRI.
Conventional methods for identifying neoplastic masses are time-consuming and require expert effort. To prevent metastasis, it is crucial to start treatment quickly. Electrochemical biosensors can identify tumor markers in colorectal cancer (CRC), hepatocellular carcinoma, prostate, breast, lung, gastric, cervical, liver cancers, colorectal cancer (CRC), and leukemia even detect simultaneously biomarkers in cases of leukemia.
Biosensors are tools that Identify biological analyte and converting it into an electrical signal that can be recognized. These tools consist of three parts: recognition element, signal transducer, and signal processor to displays the findings.in this review, we summarized biosensor's role Especially electrochemical types in detect of diseases and cancers biomarkers and subsequently Early initiation of treatment in the golden period of diseases, especially cancers.
Methods: Methods: A targeted search was done in electronic databases such as PubMed, google scholar and science direct. Relevant and up-to-date studies were selected to further analysis.
Results: Results: use of electrochemical biosensors allows for more sensitive and precise measurement of blood glucose level , biomarkers such as myoglobin ، B-type natriuretic peptide(BNP) ، Cardiac troponin 1 (c Tn I)، C-reactive protein (CRP) ، Interleukins and Interferons, dopamine and concentration of beta-amyloid in blood or CSF in cardiac and neurodegenerative diseases and tumor markers like CEA and Her-2, NSE, PSA and multiple biomarkers, such as CEA and ALF in Cancers such as breast ,lung , prostate and leukemia.
Conclusion: Conclusion: Researchers have reached the conclusion that the utilization of biosensors as cost-effective, rapid, and exceptionally sensitive diagnostic tools can lead to swift outcomes in the eradication of diseases and subsequently enhance medical treatments especially in developing countries and low-income areas.