مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Fumaria parviflora causes the improvement of blood oxidative factors and tissue parameters of the testis in streptozotocin-induced type 1 diabetic rats
Fumaria parviflora causes the improvement of blood oxidative factors and tissue parameters of the testis in streptozotocin-induced type 1 diabetic rats
Mohammad Sadegh Gholami Farashah,1,*
1. Department of Biology and Anatomical Sciences, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Introduction: According to an estimation in 2010, there are 48.5 million infertile couples in the world among whom males include 40%-50% of the cases. Diabetes is considered as one of the reasons which causes fertility problems. Oxidation-reduction balance disrupts due to hyperglycemia and an increase in free radicals and thus cellular activities. Using antioxidant and free radical scavenger supplementations can have positive effects on spermatogenesis. Fumaria parviflora is one of the plants with different antioxidant components. This study was conducted to survey the effect of F. parviflora extract on oxidative stress and spermatogenesis failure in diabetic male rats which were induced with streptozotocin.
Methods: 28 male Wistar rats were utilized and randomly divided into 4 groups including control group (G1), diabetic control group (G2, DC), diabetic treated with F. parviflora extract (G3), and healthy group (G4) that received F. parviflora extract. In addition, the therapy lasted for 56 days. Then, the blood levels of some markers of oxidative stress and histologic factors, as well as sperm parameters were assayed.
Results: The histological examination showed a negative change in the DC group, and they were included in the treated groups. The plasma levels of glutathione peroxidase (GPx) and superoxide dismutase (SOD) significantly reduced in the DC group while the malondialdehyde (MDA) level enhanced the duration of diabetes. As regards the sperm parameters, the results demonstrated that treatment with FP extract led to an increase in the quality of sperm.
Conclusion: Based on the results of the present research, the F. parviflora extract has a positive role in protecting the testis tissue and sperm quality against oxidative stress in diabetic rats.