مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Nanogels as a Versatile Drug Delivery System for Brain Cancer
Nanogels as a Versatile Drug Delivery System for Brain Cancer
Fatemeh Davodabadi,1,*
1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Introduction: A nanogel is an effective system for delivering drugs locally or systemically that is based upon a three-dimensional polymeric network. In nanomedicine, nanogels are a promising innovation for delivering bioactive. Therapeutic effects can be achieved with minimal side effects with these nanocarriers. For the treatment of brain cancer, nanogels offer the possibility of patient-centered treatment, which is a promising tool.
Methods: This is an overview study. The keywords “Nanogel”, “Brain cancer”, and “Treatment” were used for Science databases the search in PubMed, Scopus, Google Scholar, and Web of for studies published.
Results: During surgery, nanogels could be injected after tumor tissue is removed to provide a protective layer or fill the resection cavity where the tumor was removed. Additionally, nanogels are capable of carrying a variety of therapeutic agents that can be applied to prevent the recurrence of tumors. There is also evidence that administration of diluted nanogels intravenously and locally promotes selective accumulation of nanogels in brain tumor tissues. Intranasal delivery of therapeutic agents through nanogels could also be used to target brain tumor tissues before or after surgery.
Conclusion: Future treatments of brain cancer could benefit from nanogel technology, which is viable, lucrative, and efficient. Various treatments using nanogels can be offered both locally and systemically, which respects the Blood-Brain Barrier (BBB) as well as the physiological features of the cranial cavity.