• Investigation of the Effects of Simvastatin on Lipid Peroxidation and Catalase Activity in the Hippocampus of Bisphenol A-Exposed Rats
  • Ali Nikzad,1,* Delaram Eslimi Esfahani,2 Vahidehsadat Abbasnia,3 Adel Salari,4
    1. Department of Animal Science, Faculty of Biological Science, Kharazmi University, Tehran, Iran
    2. Department of Animal Science, Faculty of Biological Science, Kharazmi University, Tehran, Iran
    3. Department of Biology, Payame Noor University, Tehran, Iran
    4. Department of Animal Science, Faculty of Biological Science, Kharazmi University, Tehran, Iran


  • Introduction: Bisphenol A (BPA) is a widespread environmental toxin capable of crossing the blood-brain barrier and inducing biochemical damage in brain tissue. It increases lipid peroxidation and suppresses antioxidant defenses. Simvastatin, beyond its lipid-lowering properties, also exhibits antioxidant potential. This study aimed to evaluate the effects of simvastatin on hippocampal levels of malondialdehyde (MDA) and catalase (CAT) activity in rats exposed to BPA.
  • Methods: Fifty-six male Wistar rats were randomly divided into seven groups, including control, BPA (0.4 mg/kg/day), simvastatin-only (30 mg/kg/day), and three BPA-treated groups receiving simvastatin at 10, 20, or 30 mg/kg/day. All treatments were administered orally for 4 weeks. At the end of the experiment, MDA levels and CAT activity were measured in hippocampal tissue. Statistical analysis was performed using ANOVA (p < 0.05).
  • Results: BPA administration led to a marked elevation in hippocampal MDA levels and a significant reduction in CAT activity compared with the control group (p < 0.05). Treatment with simvastatin mitigated these changes in a dose-responsive manner, lowering lipid peroxidation and restoring catalase activity significantly (p < 0.05).
  • Conclusion: Simvastatin ameliorates BPA-induced oxidative alterations in the hippocampus by modulating lipid peroxidation and catalase activity, suggesting its potential as a neuroprotective agent.
  • Keywords: Bisphenol A, Simvastatin, Lipid Peroxidation, Catalase,Rat