مقالات پذیرفته شده در نهمین کنگره بین المللی زیست پزشکی
Examining the Role of Inulin in Colorectal Cancer: Mechanisms and Therapeutic Potential
Examining the Role of Inulin in Colorectal Cancer: Mechanisms and Therapeutic Potential
Fatemeh Abolmashadi,1Mahdi Moridi Farimani,2,*
1. Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran 2. Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
Introduction: Colorectal cancer (CRC) remains one of the leading causes of illness and cancer-related mortality worldwide, with dietary factors playing a significant role in its onset and prevention. Among the diverse components of diet, inulin—a naturally occurring prebiotic fiber of the fructan type found in many plants—has garnered significant attention for its potential protective effects against colorectal cancer (CRC). This study indicates that the prebiotic inulin may serve as a therapeutic alternative capable of targeting colorectal cancer cells while also fostering beneficial gut microbiota.
Methods: A comprehensive analysis was conducted via a systematic search across both the PubMed and Springer databases. The review concentrated on topics relevant to colorectal cancer, prebiotics, inulin, and other important terms such as microbiota and apoptosis. Articles that did not meet the established criteria were omitted from consideration. In the end, 26 references were selected for this review, as they provided the essential information and data.
Results: Colorectal cancer is a multi-stage disease that progresses from genetic mutations to adenomatous polyps, ultimately resulting in invasive and metastatic cancer. The bacterial species residing in the large intestine influence tumor development through the metabolism of dietary components. Research indicates that inulin alters the gut microbiota composition by promoting the growth of beneficial bacteria such as Bifidobacterium and Lactobacillus, and enhances the production of short-chain fatty acids (SCFAs), particularly butyrate, which may provide protective effects against the risk of colorectal cancer and its progression by inducing apoptosis. In a mouse model, inulin has been shown to inhibit aberrant crypt foci (ACF), a well-known biomarker for colorectal cancer. Conversely, the combination of Lactobacillus acidophilus and inulin has been found to reduce ACF expression in the large intestine, thereby decreasing the risk of developing colorectal cancer. Furthermore, clinical trials involving Lactobacillus rhamnosus, Bifidobacterium lactis, and inulin have demonstrated a reduction in colorectal cancer risk by inhibiting cellular proliferation, necrosis, and maintaining the integrity of the epithelial barrier. However, there are limited human studies reported on this matter, indicating a need for more extensive and precise research.
Conclusion: Consequently, this research indicates that inulin, recognized as a natural prebiotic, holds considerable promise in both the prevention and management of colorectal cancer by enhancing the makeup of the intestinal microbiota and boosting the synthesis of anticancer metabolites. Notwithstanding encouraging preclinical findings, extensive, controlled clinical trials are essential to validate its safety, determine the optimal dosage, and assess its practical effectiveness in human subjects. The utilization of inulin can be considered as a complementary and cost-effective solution alongside conventional treatments.