Introduction: AIDS is a disease which is caused due to infection with HIV virus, and is detected by severe immune suppression associated with opportunistic infections, malignant tumors, emaciation and Central Nervous System. This study was investigation between serum homocysteine of HIV-infected men and women and correlation with CD4+ lymphocyte in healthy men and women.
Methods: This study was designed by case/control and included 228 samples (114 HIV-infected male and female and 114 healthy male and female) which was as sampling of clinical population and were selected from Imam Khomeini hospital complex. The tools used in this study were flow cytometer and Spectrophotometer and the data collection were by data collection were by data entry forms and case study. In addition the data analyses used for this research was the T-Test for independent groups and also to calculate the correlation coefficient the Pearson test was used.
Results: Results showed that between TCD4+ less than 200 count and the Homocysteine serum level there was no significant correlation between Homocysteine in the sample (p˃0.05). Also, between TCD4+ more than 200 counts and Homocysteine levels in the samples, there was a significant correlation (p<0.01). In addition, between the serum Homocysteine levels and age in the sample there was no correlation (p<0.05). Also, average Homocysteine between men and women with HIV whose CD4+ were over 200 and less than 200 there was no significant difference (p˃0.05). Also, between average Homocysteine in men and women with CD4+ above 200 and people with HIV and normal with CD4+ above 200 there was no significant difference (p˃0.05).
Conclusion: This study demonstrated that the level of serum homocysteine in people infected with HIV is higher than normal. In other words, one of the leading causes of death in patients is myocardial infarction. By examining the effect of homocysteine in HIV positive patients and its relationship with the level of TCD4+ cells and understanding its effect on myocardial infarction, treatment measures can be targeted in specific populations at risk and the mortality of HIV patients due to stroke can be decreased heart rate. In addition the number of CD4+ and CD8+ of people with HIV is lower than normal.