• Functional mechanism of miR-1270 in cancer development
  • Anita Alizadeh,1,*
    1. M.SC. student of Genetics, Department of Biology, Higher Education Institute of Rab-Rashid, Tabriz, Iran


  • Introduction: Cancer is one of the most leading causes of death in the worldwide. Common cancer treatment methods such as surgery, chemotherapy and hormone therapy are limited to the early stages of cancer development. Therefore, it is necessary to develop novel therapeutic methods which are more beneficial and have fewer complications. Furthermore, discovering new prognostic and diagnostic biomarkers for early detection of cancer is very helpful to more effective treatment. microRNAs (miRNAs) are categorized as short non coding RNAs which have 22 nucleotides in length and highly conserved through out evolution. They are considered one of the important regulatory mechanisms of gene expression by interaction with 3′ untranslated regions (3′-UTR) of mRNAs and subsequently lead to mRNA translation suppressing or degradation of mRNA. According to miRNA target databases, one miRNA may regulate several mRNAs and its targets whereas One mRNA may be targeted by various miRNAs. Among numerous functional miRNAs which may be associated with human cancers, miR-1270 have been shown that has pivotal role in cancer cell development and aberrant expression of this miRNA have been illustrated in different types of cancer.
  • Methods: In this review data were obtained from searching the scientific resources including PubMed, google scholar, science direct and library resources and related books, For aim to know miR-1270 regulatory mechanism and its interaction with other genes and signaling pathways in cancer development.
  • Results: Studies have shown that miR-1270 has high expression in several cancer such as thyroid, osteosarcoma and lung cancer and upregulated expression of it may has interaction with signaling pathways including NF-kappaB and wnt signaling pathways. Moreover miR-1270 can be regulated by circular RNAs (circRNAs) such as circRNA Cdr1as, circ sox4 and circ0001247 also with such lncRNAs including SNHG8, GLIDR in various types of cancer furthermore it has been demonstrated that miR-1270 may interact with interferon-alpha1 and its nature antisense mRNAs to modulate homeostasis in human cells.
  • Conclusion: It was concluded that miR-1270 mainly functions as an oncogene in different cancers, there were also significant association between miR-1270 and other ncRNAs in tumor cells. Moreover miR-1270 has a critical role during tumor progression using the regulation of signaling pathways and may act as a novel biomarker in cancer diagnosis and treatment.
  • Keywords: Non coding RNA, MicroRNA, MiR-1270, Cancer, Biomarker.