مقالات پذیرفته شده در پنجمین کنگره بین المللی زیست پزشکی
Vitamin D receptor(VDR) expression as a prognosis and differential factor in acute myeloid leukemia(AML)
Vitamin D receptor(VDR) expression as a prognosis and differential factor in acute myeloid leukemia(AML)
saman saeidi,1,*reyhane shaddel,2
1. golestan university of medical sciences(goums) 2. golestan university of medical sciences(goums)
Introduction: Acute myeloid leukemia(AML) is one of the most common kind of leukemia with weak prognosis. vitamin D is effective in immune system and cell division and together with its receptor(VDR),play an important role in many signaling pathways which cause cancer progression.
VDR gene is polymorphic ( SNP family) Its forms have been studied in relation to the risk of disease in several cancers.in leukemia, Taq I has the most relation with AML among 4 known important polymorphisms.in this review, our goal is to demonstrate beneficial role of VDR in prognosis of AML and its subtypes.
Methods: documentations in this review article are gathered by searching key words such as “Acute Myeloid Leukemia” “VDR” “Prognostic factors” in date bases like PUBMED,GOOGLE SCHOLAR and SCOPUS. At last we chosen 7 article with most related data among 11 that published in last 5 years.
Results: by very important signaling pathways such as MAPK and P13K, VDR play spectacular role in Cell differentiation and by suppressing cancer cells and promoting the proliferation and differentiation of malignant cells, it play role as a Anti-leukemic factor.
Given that more immature phenotypes lead to more dangerous prognosis and outcomes, In the field of blood disorders and various subfields of AML, it was observed that VDR null( -/- ) mouses develop to have disorders in The process of maturation of myeloid cells.
On the other hand, AML subtypes with monocyte differentiation (AML4, AML5) have higher VDR expression compared to immature subtypes. In general, VDR expression seems to be lower in people with AML than in healthy individuals.
Conclusion: in the end, it appears that VDR as a new genetic modulator with its significant role in cell maturation and differential and its Anti-leukemic nature, can play role as a prognosis and differential factor in Acute Myeloid Leukemia.
in future, vitamin D and its analogs (specially VDR) can be used in cancer treatment which need more research and information.