Application of Bone Marrow Stromal Cells in Chemotherapy-induced Premature Ovarian Failure

Application of Bone Marrow Stromal Cells in Chemotherapy-induced Premature Ovarian Failure
Fatemeh Mohebi,^1,* Mina Soleimani,² Hanane Hamidi,³
1. Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2. Iran University of Medical Sciences, Tehran, Iran
3. Khalkhal University of Medical Science, Khalkhal, Iran
Introduction: Introduction: Female infertility is a worldwide therapeutic condition that can be caused by various reproductive system-related diseases, including premature ovarian failure (POF) and polycystic ovary syndrome (PCOS). Even though chemotherapy drugs can reduce the tumor cell's growth, they can also cause premature ovarian failure and consequently female infertility. It affects the quality of both the physical and mental health of patients. As a possible cell-based treatment, Mesenchymal stem cells (MSCs) have obtained rising attention. Bone marrow-derived mesenchymal stem cells (BMSCs) feature advantages such as self-replication, multidirectional differentiation, convenient source, ability to avoid immune rejection, and lack of ethical issues. Moreover, BMSCs have extensive utilization potential in the regenerative medicine, including reproductive dysfunction.
Methods: Methods: The data were collected using 15 articles in Pub Med and Science Direct, between 2014 and 2021 by using keywords BMSC, POF, Mesenchymal stem cells.
Results: Results: 4 pieces of research have shown advantageous effects of BMSCs therapy in a chemotherapy-induced ovarian failure in animal models. Especially the results demonstrated that bone marrow stromal cells can restore ovarian structure and functions. After all, the beneficial effects of BMSC treatment in clinical trials is not adequately to certify that most POF patients will repair their ovarian reserve.
Conclusion: Conclusion: The purpose of the current study was to determine the beneficial effects of bone marrow stromal cells on ovarian dysfunctions. BMSCs are a good candidate for transplantation in ovarian dysfunction because of their low immunogenicity, also they can be obtained easily and amplified in large quantities in vitro but BMSCs are not widely applied in clinical therapy.
Keywords: Keywords: BMSC, POF, Mesenchymal stem cells