Gene expression study of disrupted in schizophrenia 1 (disc1) in schizophrenia and paranoid personality disorder

Maryam Ghorbanzadeh,1,* Arvin haghighatfard,2 Shohreh zare,3

1. varamin pishva Branch, Islamic Azad university
2. Tehran North branch , Islamic Azad University
3. varamin pishva Branch, Islamic Azad university



Schizophrenia (scz) is a psychiatric disorder with no clarify etiology or biological diagnosis.paranoid personality disorder (ppd) is one of the type a personality disorder characterized by paranoia and generalized mistrust. disrupted in schizophrenia 1 (disc1) is a gene located on human chromosome 1 which is involved in development of central nervous system. variations and translocations in this gene were found associated with schizophrenia and other psychiatric disorders. present study aimed to evaluate the expression alteration of disc1 gene in peripheral blood of scz and ppd patients.


Study was included 50 scz, 50 ppd and 50 non-psychiatric individuals. total blood was collected and expression level of disc1 evaluated by using quantitative real time pcr sybr green. also, to assess psychiatric symptoms severity, positive and negative syndrome scale (panss) was obtained from scz and ppd patients


Results showed significant disc1 gene down regulation in scz and ppd patients vs. non-psychiatrics. disc1 protein levels were significantly decreased in scz and ppd vs. non-psychiatrics. also in scz patients, general and negative symptoms score were associated with down regulation of disc1 mrna level.


Present study revealed disc1 as potential peripheral marker for schizophrenia as well as paranoid personality disorder. correlation between disc1 mrna level reduction and severity of general and negative symptoms side may support the neurodevelopmenthypothesis about etiology of schizophrenia and related personality disorder especially paranoid personality disorder.


Schizophrenia; paranoid personality disorder; disc1