1. varamin pishva Branch, Islamic Azad university 2. Tehran North branch , Islamic Azad University 3. varamin pishva Branch, Islamic Azad university
Abstract
Introduction
Schizophrenia (scz) is a psychiatric disorder with no clarify etiology or biological diagnosis.paranoid personality disorder (ppd) is one of the type a personality disorder characterized by paranoia and generalized mistrust. disrupted in schizophrenia 1 (disc1) is a gene located on human chromosome 1 which is involved in development of central nervous system. variations and translocations in this gene were found associated with schizophrenia and other psychiatric disorders. present study aimed to evaluate the expression alteration of disc1 gene in peripheral blood of scz and ppd patients.
Methods
Study was included 50 scz, 50 ppd and 50 non-psychiatric individuals. total blood was collected and expression level of disc1 evaluated by using quantitative real time pcr sybr green. also, to assess psychiatric symptoms severity, positive and negative syndrome scale (panss) was obtained from scz and ppd patients
Results
Results showed significant disc1 gene down regulation in scz and ppd patients vs. non-psychiatrics. disc1 protein levels were significantly decreased in scz and ppd vs. non-psychiatrics. also in scz patients, general and negative symptoms score were associated with down regulation of disc1 mrna level.
Conclusion
Present study revealed disc1 as potential peripheral marker for schizophrenia as well as paranoid personality disorder. correlation between disc1 mrna level reduction and severity of general and negative symptoms side may support the neurodevelopmenthypothesis about etiology of schizophrenia and related personality disorder especially paranoid personality disorder.
