The effect of nigella sativa oil on serum lipids level in non-alcoholic fatty liver male rats

Mojgan Rahimi,1,*



Metabolic disorders, such as lipid disorders, are related to progression of non-alcoholic fatty liver disease (nafld) and cause cardiovascular problems. due to concerns about the long-term effects of chemical drugs, the use of natural compounds as alternatives or complementary treatments has been considered more than ever. so the aim of present study was to investigate the effect of nigella sativa oil on serum levels of lipids in non-alcoholic liver of rats.


In this experimental study, 24 male rats were divided into 3 groups. control group: under the normal diet. the control group received 6 weeks of high-fat diet for induction of fatty liver and then received saline oral administration for 3 normal weeks. experimental group: first they were subjected to high fat diet and then were fed orally with 5 ml/kg nigella sativa oil for 5 weeks. at the end of this period, blood samples were collected from animals for measuring serum levels of lipids and serum level of cholesterol and hdl levels were measured in serums. one-way anova was used to analyze the variables mean in the groups.


Fatty liver induction cause to reduced cholesterol (p = 0.001) and hdl (p = 0.001) in rats. the use of nigella sativa oil increased cholesterol in rats compared to the control group (p = 0.001). hdl levels of group that consumed nigella sativa oil were significantly lower than control group (p = 0.006).


Use of nigella sativa oil can increase cholesterol levels in non-alcoholic fatty liver rats normal level.


Non-alcoholic fonatty liver, nigella sativa oil, serum lipids