The anaesthetic ketamine is used to treat various chronic pain syndromes. the side effects of ketamine noted in clinical studies. ketamine induced synaptic and long-term spatial memory impairment. other studies showed preventive effect of curcumin in inhibiting brain inflammation and memory dysfunction. curcumin in high dosage can improve memory. despite of this wide range of therapeutic activity, curcumin like other flavonoids has a major limitations in bioavailability and absorption. our research investigates the protective effects of curcumin and nano phytosome of curcumin on memory impairment induced by ketamine.
In this study, animals were divided into 7 groups: control, disease, positive control and 2 treatment groups, which received curcumin and curcumin nano phytosome in a dose of 15 mg / kg for 15 days. the control and patient groups receive distilled water by gavage method. mice in all group expect control and positive control, were injected with ketamine (30 mg/kg; i.p.) for 14days. curcumin and curcumin nano phytosome in a (15 mg/kg) was gavagely administered after ketamine administration. finally, memory and learning was investigated by novel object test.
Our results indicated that ketamine treatment (30mg/kg, for 14 days) induced memory dysfunction in the novel object test. the discrimination index in the disease group significantly (p <0.01) decreased compared with the control group. also treatment with curcumin and nano phytosome of curcumin increases in this index (p <0.5).
Overall findings suggest the beneficial effect of nano phytosome curcumin on the prevention memory dysfunction induced by ketamine in mice.