Gastric cancer is one of the most commonly diagnosed cancer and the second leading cause of cancer death world wide.current treatment for gastric cancer includes aggrasive number of patients with median survival of optimal treatment rather dismal.failure in conventional treatment for gastric cancer reflects a strong need to develop novel therapeutic approches.reccent advances in gene therapy with nanoparticles offer novel apportunities for treatment.nanoparticles are tiny materials having size ranges from 1 to 100 nm. due to their small size they have various applications in different sciences.
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In this study,we find that nano carriers as a non viral vectors in comparision to viral vectors have less cytotoxicity and less stimulate immune.in addition,gene transfer system with nanoparticles are not limited by the size of gene molecules that are introduced into the cell and its also easy to produce and transform this vectors on large scale.these nanoparticles are cationic and have a positive charge that bind with negative charge of dna by electrostatic interaction and forming a stable complex.after the complex targeted to desired tissue,inters in target cell and finally cause to express,restore or inhibit a particular gene in the nucleus and lead to apoptosis or restore tumor cells to the normal modes.
Gene therapy with nanoparticles is an emerging treatment modality and such as many other treatment methods have an advantages and disadvantages that is requires further researchs to evaluate the efficiency of this methods.