Application of ag, zno and cuo nanoparticle on wound healing: a review

Mahdi Bayrami,1,* Faezeh nasrollahi nia,2 Milad feyzollahi,3 Danial bajgiran,4 Sanaz alioghli,5 Amin bayrami,6

1. Department of Biology, University of Mohaghegh Ardabili, Ardabil, Iran.
2. Department of Biology, University of Mohaghegh Ardabili, Ardabil, Iran.
3. Department of Biology, Faculty of Science, University of Mohaghegh Ardabili
4. Department of Biology, University of Mohaghegh Ardabili, Ardabil, Iran.
5. Department of Biology, University of Mohaghegh Ardabili, Ardabil, Iran.
6. Faculty of medicine science, Azad University of Sari, Sari, Iran.

Abstract

Introduction

Wound healing still remains a challenging clinical problem for which efficient wound management is necessary. there is a desire for novel strategies to achieve expeditious wound healing because of the enormous financial burden worldwide. in recent decades, researchers have focused on the development of nanotechnology. drug delivery systems are expanding to meet the specific goal and increasing the burden of treatment using nanotechnology. to minimize wound infections, they often use disinfectants to coat the wound. the aim of this study is investigate application of ag, zno and cuo nanoparticle on wound healing.

Methods

To this purpose, we conducted extensive library research and compiled the latest reports of application these nanoparticles on wound healing.

Results

Silver (ag0 or ag+) has strong antimicrobial properties and is known to deal with a wide range of bacteria. in addition to antimicrobial properties, silver also has anti-inflammatory properties. the reports suggest that zno nanoparticles could induce proliferation and migration of endothelial cells and led to the formation of new blood vessels. further, zno nanoparticles can act as h2o2 generators in the tissue engineering structure, which act as key regulators that increase cell proliferation and wound healing. also, it has been shown that copper (cuo) contributes to the process of wound healing by increasing angiogenesis by inducing vascular endothelial growth factor production as well as increased expression of integrin. copper also improves wound healing by increasing the stability and constancy of fibrinogen and collagen and activating copper-dependent enzymes and important polysaccharides that are important for matrix regeneration, cell proliferation and cell renewal.

Conclusion

In conclusion, nanotechnology-based therapy has recently announced itself as a possible next-generation therapy that is able to advance wound healing to cure chronic wounds, on the other hand the nanoparticles can be synthetized with natural products to enhance synergistic effects.

Keywords

Nanotechnology, wound healing, zno, ag, cuo