Fecal microbiota transplantation (fmt) as a new treatment for clostridium difficile infection (cdi): a literature review

Nastaran Shah sanaie,1 Mohammad rabbani khorasgani,2,*

1. Department of Biology , Faculty of Sciences, University of Isfahan
2. Department of Biology , Faculty of Sciences, University of Isfahan



During recent decades, clostridium difficile infection (cdi) has expressed increase in severity, morbidity, and mortality. some important challenges such as drug resistance, gut microbiota change, and high expenses, have led scientists to develop fecal microbiota transplantation (fmt) as a new treatment for cdi. at this review, the rationale, methods, and potential applications of fmt especially for treatment of cdi have been discussed.


This study was conducted using library research method and databases searching.


Fmt is regarded as a suitable method for gut microbiota regulation. improved colon microbial community, deal with c. difficile by different mechanism such as competition for nutrients, producing antimicrobial peptides, prevention of spore germination and vegetative growth by, and activation of immune response. according to some documents, this method has been successful in 90% of patients.


In recent years, the incidence of clostridium difficile infection has increased significantly and antibiotic therapy could not always successful in treatment of patients. fmt has a high potential to be used remedy of recurrent cdi. at this method gut microbiota improved and prevent spore germination. fmt regulates the intestinal microbial population which can be a simple and inexpensive way to deal with other intestinal infections. however, some questions should be answered and clinical use of this method requires further studies.


Clostridium difficile infection, fecal microbiota transplantation (fmt), gut microbiota regulation