• Stem cells and bone regeneration: a review
  • Nayereh Ahmadian,1 Nafiseh Baheiraei,2,*
    1. Bio-material Engineering Department, Faculty of Interdisciplinary sciences and technologies, Tarbiat Modares University
    2. Tissue Engineering & Applied Cell Sciences Division, Department of Hematology, Faculty of Medical science, Tarbiat Modares University


  • Introduction: Bone defects caused by diseases and trauma have become a global concern with high incidence, which seriously affect the health and life quality of the whole population and lay a heavy financial burden on society. Cellular therapy which has gained an increasing popularity in recent years, uses cells directly or indirectly for their potential therapeutic benefit. Stem cells have shown healing capability by improving angiogenesis and preventing fibrosis, which could have a role in tissue repair and regeneration. The objective of this work was to review the previous researches on stem cells therapy for bone regeneration ;comparing with other current treatments.
  • Methods: Electronic databases were searched.
  • Results: • Mesenchymal stem cells (MSCs) have the potential to differentiate into bone, cartilage, or fat tissue. • Implantation of cells in combination with scaffolds results in greater bone regeneration compared with transplantation of cells alone.
  • Conclusion: MSCs have therapeutic potential holding several advantages over conventional treatments in bone regeneration . However, more research is needed to understand the mechanisms underlying their therapeutic efficacy which could direct clinical decision-making.
  • Keywords: Bone regeneration,Cell therapy, Mesenchymal stem cells, Scaffolds