Introduction: An antibiotic is a chemical substance, produced by micro-organ- isms, which has the capacity to inhibit the growth of and even to destroy bacteria and other micro-organisms.
Sulfonamides derived from sulfanilamide ( p-aminobenzenesulfonamide) are commonly referred to as sulfa drugs. Although several drug classes are characterized by the presence of a sulfonamide function, eg, hypoglycemics, carbonic anhydrase inhibitors, saluretics, and tubular transport inhibitors, the antibacterial
sulfonamides have become classified as the sulfa drugs.
Methods: In this study, we began by synthesizing the basic structure of silver sulfadiazine, which initially protected aniline with acetic anhydride so that nitrogen would lose its activity and would not react. In the next step, chlorosulfonic acid is added to the synthesis medium and is expected to bond from the para to the aniline structure then 5-aminotetrazol is added to the reaction and the sulfatetrazone structure is formed. 1 is added to the product obtained, and the final material is silver sulfatetrazone.
Results: The efficacy of the synthesized material on the bacteria of Escherichia coli and Bacillus cereus has been investigated by MIC and MBC, which have been shown to have significant efficacy, as well as through synthesized structure IR and NMR methods, which indicate that the synthesis has been performed correctly
Conclusion: In this study, we sought to improve the structure of silver sulfadiazine, a widely used drug for the treatment of burn-related bacterial infections. Ultimately, we will get a structure that shows better performance at a faster rate of efficacy. As a result, fewer drugs are expected to be used in the amount and length of treatment reduced and drug side effects reduced.