Introduction: Metal–organic frameworks (MOFs), which are typically embedded in polymer matrices as composites, are emerging as a new class of carriers for sustained drug delivery.Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect.
Methods: In this study, a new BTC-based ligand was synthesized in the laboratory. The solution used was acetone at all stages. BTC ligand is first activated by DCC (coupling reagent) and then by NHS addition, and ethylene dimine is then bound to BTC and finally phthalic anhydride ligand is added to form a bulk BTC-based ligand.
In the next step, the synthesized ligand with copper metal salt was autoclaved in water and ethanol solvent and synthesized MOF under high pressure and temperature.
Results: MOF structures, due to the presence of nano-pores, significantly pull the drug in and release the drug slowly to the target site. Initial investigations for the proper synthesis of the synthesis by IR and NMR confirm the synthesized structure.
Conclusion: In this study we attempted to synthesize larger-size ligand green synthesis methods and ultimately to synthesize MOF with significant porosity which performs better than other synthesized MOFs in the past. Larger porosity of drug better And more absorbed and the functional groups of the ligand structure will be slowed down by good absorption of the drug.